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  1. A 資料種別
  2. 010 東京女子医科大学雑誌
  3. 010A 論文
  4. 76巻
  5. 1号

後天性嚢胞性腎疾患における増殖性嚢胞の組織学的分類 : 多段階発癌モデルとしての透析腎癌

http://hdl.handle.net/10470/27046
http://hdl.handle.net/10470/27046
f3b7521a-5a12-4c05-912b-d7bd85b7bc5f
名前 / ファイル ライセンス アクション
KJ00006017986.pdf KJ00006017986.pdf (1.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-08-10
タイトル
タイトル 後天性嚢胞性腎疾患における増殖性嚢胞の組織学的分類 : 多段階発癌モデルとしての透析腎癌
言語
言語 jpn
資源タイプ
資源タイプ journal article
別タイトル
その他のタイトル Histological Classification of Proliferative Cysts in Acquired Cystic Disease of the Kidney : Renal Cell Carcinoma in Dialysis Patients as a Model of Multistep Carcinogenesis
著者名 飯塚, 淳平

× 飯塚, 淳平

WEKO 293507

飯塚, 淳平

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橋本, 恭伸

× 橋本, 恭伸

WEKO 293508

橋本, 恭伸

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伊藤, 文夫

× 伊藤, 文夫

WEKO 293509

伊藤, 文夫

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東間, 紘

× 東間, 紘

WEKO 293510

東間, 紘

Search repository
著者別名
姓名 IIZUKA, Jumpei
著者別名
姓名 HASHIMOTO, Yasunobu
著者別名
姓名 ITO, Fumio
著者別名
姓名 TOMA, Hiroshi
出版者
出版者 東京女子医科大学学会
受付日付
ISSN
収録物識別子タイプ ISSN
収録物識別子 0040-9022
NCID
収録物識別子タイプ NCID
収録物識別子 AN00161368
書誌情報 東京女子医科大学雑誌

巻 76, 号 1, p. 24-30, 発行日 2006-01
著者版フラグ
抄録
内容記述タイプ Abstract
内容記述 Long-term dialysis is known to induce development of renal cell carcinoma (RCC) from acquired cystic disease of the kidney (ACDK), but no pathological patternization has been determined for the presumably multistep carcinogenesis. Proliferative cystic epithelia in ACDK were pathologically classified to evaluate multistep carcinogenesis, and frequency analysis suggested a tentative process for multistep carcinogenesis. Approximately 100 cysts each from 20 surgically resected RCCs with ACDK (total, 1,752 cysts) were analyzed. Prior to analysis, 300 randomly selected sites of proliferative cysts underwent histological classification of cystic epithelia. Type I represented single-layer cystic epithelia (Ia, flat ; Ib, cuboidal). Proliferative cystic epithelia comprised : Type II, pseudostratification ; Type III, papillary proliferation; and Type IV, cells forming networks among epithelia. Single-layer epithelia comprised 81.7% Type la and 18.3% Type Ib. All proliferative epithelia intermingled with single-layer cystic epithelia, with 96.3% accompanying Type Ib. Compared with only 1% of Type Ia, 65% of Type Ib showed proliferative lesions (Type II, >50% ; Type II + III, 21% ; Type II + IV, 18%). Histological classification appeared valid. Presence of Type Ib may be critical to proliferative lesion development. Carcinogenesis may involve Type Ib pseudostratification followed by morphological changes involving papillary formations and anastmosing networks.
著者所属
東京女子医科大学医学部泌尿器科学
著者所属
東京女子医科大学医学部泌尿器科学
著者所属
東京女子医科大学医学部泌尿器科学
著者所属
東京女子医科大学医学部泌尿器科学
著者キーワード
主題 acquired cystic disease of the kidney
著者キーワード
主題 ACDK
著者キーワード
主題 renal cell carcinoma in dialysis patients
著者キーワード
主題 multistep carcinogenesis
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