{"created":"2023-06-20T17:00:22.034553+00:00","id":19747,"links":{},"metadata":{"_buckets":{"deposit":"60e127c4-98d7-41e0-b107-f0b2a10a96c3"},"_deposit":{"created_by":3,"id":"19747","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19747"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00019747","sets":["140:1307:1308:2004:2005"]},"author_link":["293512","293514","293510","293507","293509","293508","293513","293511"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Histological Classification of Proliferative Cysts in Acquired Cystic Disease of the Kidney : Renal Cell Carcinoma in Dialysis Patients as a Model of Multistep Carcinogenesis"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"30","bibliographicPageStart":"24","bibliographicVolumeNumber":"76","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"飯塚, 淳平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"橋本, 恭伸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 文夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東間, 紘"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Long-term dialysis is known to induce development of renal cell carcinoma (RCC) from acquired cystic disease of the kidney (ACDK), but no pathological patternization has been determined for the presumably multistep carcinogenesis. Proliferative cystic epithelia in ACDK were pathologically classified to evaluate multistep carcinogenesis, and frequency analysis suggested a tentative process for multistep carcinogenesis. Approximately 100 cysts each from 20 surgically resected RCCs with ACDK (total, 1,752 cysts) were analyzed. Prior to analysis, 300 randomly selected sites of proliferative cysts underwent histological classification of cystic epithelia. Type I represented single-layer cystic epithelia (Ia, flat ; Ib, cuboidal). Proliferative cystic epithelia comprised : Type II, pseudostratification ; Type III, papillary proliferation; and Type IV, cells forming networks among epithelia. Single-layer epithelia comprised 81.7% Type la and 18.3% Type Ib. All proliferative epithelia intermingled with single-layer cystic epithelia, with 96.3% accompanying Type Ib. Compared with only 1% of Type Ia, 65% of Type Ib showed proliferative lesions (Type II, >50% ; Type II + III, 21% ; Type II + IV, 18%). Histological classification appeared valid. Presence of Type Ib may be critical to proliferative lesion development. Carcinogenesis may involve Type Ib pseudostratification followed by morphological changes involving papillary formations and anastmosing networks.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"293511","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IIZUKA, Jumpei"}]},{"nameIdentifiers":[{"nameIdentifier":"293512","nameIdentifierScheme":"WEKO"}],"names":[{"name":"HASHIMOTO, Yasunobu"}]},{"nameIdentifiers":[{"nameIdentifier":"293513","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ITO, Fumio"}]},{"nameIdentifiers":[{"nameIdentifier":"293514","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TOMA, Hiroshi"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"acquired cystic disease of the kidney","subitem_subject_scheme":"Other"},{"subitem_subject":"ACDK","subitem_subject_scheme":"Other"},{"subitem_subject":"renal cell carcinoma in dialysis patients","subitem_subject_scheme":"Other"},{"subitem_subject":"multistep carcinogenesis","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学医学部泌尿器科学"},{"subitem_text_value":"東京女子医科大学医学部泌尿器科学"},{"subitem_text_value":"東京女子医科大学医学部泌尿器科学"},{"subitem_text_value":"東京女子医科大学医学部泌尿器科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006017986.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006017986.pdf","url":"https://twinkle.repo.nii.ac.jp/record/19747/files/KJ00006017986.pdf"},"version_id":"805977a5-3608-4453-9501-4f61c3193677"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"後天性嚢胞性腎疾患における増殖性嚢胞の組織学的分類 : 多段階発癌モデルとしての透析腎癌","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"後天性嚢胞性腎疾患における増殖性嚢胞の組織学的分類 : 多段階発癌モデルとしての透析腎癌"}]},"item_type_id":"10001","owner":"3","path":["2005"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"19747","relation_version_is_last":true,"title":["後天性嚢胞性腎疾患における増殖性嚢胞の組織学的分類 : 多段階発癌モデルとしての透析腎癌"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T21:04:14.304982+00:00"}