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We investigated the effect of IL-10 in a mouse model of acute necrotizing pancreatitis induced by ten intraperitoneal infusion of cerulein (50 μg/kg) at hourly intervals and a single intraperitoneal injection of LPS (10 mg/kg) concomitant with the first cerulein injection. The IL-10 treated group was also injected with 10,000 U of IL-10 seven times intraperitoneally every 2 h beginning 1 h before the cerulein infusion. The pancreas was examined for histological changes and analyzed for tissue TNFα mRNA and IL-1β mRNA by RT-PCR. Serum amylase and lipase release peaked at 12 h after the first cerulein injection, but their concentrations at 12 and 24 h were significantly reduced by IL-10. Histologically, acinar cell necrosis and vacuolization were dramatically attenuated at 12 and 24 h in the IL-10 treated group, and induction of tissue TNFα mRNA and IL-1β mRNA in the pancreas was significantly reduced by IL-10. In conclusion, IL-10 is capable of decreasing the severity of experimental acute necrotizing pancreatitis. Inhibition of TNFα and IL-1β production in the pancreas may explain the protective effect of IL-10.", "subitem_description_type": "Abstract"}]}, "item_10001_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "297653", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "福屋, 裕嗣"}]}, {"nameIdentifiers": [{"nameIdentifier": "297654", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "西野, 隆義"}]}, {"nameIdentifiers": [{"nameIdentifier": "297655", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "小山, 祐康"}]}, {"nameIdentifiers": [{"nameIdentifier": "297656", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "渡辺, 伸一郎"}]}, {"nameIdentifiers": [{"nameIdentifier": "297657", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "林, 直諒"}]}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "東京女子医科大学学会"}]}, "item_10001_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00161368", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0040-9022", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_subject_47": {"attribute_name": "著者キーワード", "attribute_value_mlt": [{"subitem_subject": "IL-10", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNFα", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-Iβ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pancreatitis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mouse", "subitem_subject_scheme": "Other"}]}, "item_10001_text_35": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Department of Gastroenterology, Tokyo Women\u0027s Medical University, School of Medicine"}, {"subitem_text_value": "Department of Gastroenterology, Tokyo Women\u0027s Medical University, School of Medicine"}, {"subitem_text_value": "Department of Clinical Laboratory Medicine, Tokyo Women\u0027s Medical University, School of Medicine"}, {"subitem_text_value": "Department of Clinical Laboratory Medicine, Tokyo Women\u0027s Medical University, School of Medicine"}, {"subitem_text_value": "Department of Gastroenterology, Tokyo Women\u0027s Medical University, School of Medicine"}, {"subitem_text_value": "東京女子医科大学医学部消化器内科学"}, {"subitem_text_value": "東京女子医科大学医学部消化器内科学"}, {"subitem_text_value": "東京女子医科大学医学部臨床検査科"}, {"subitem_text_value": "東京女子医科大学医学部臨床検査科"}, {"subitem_text_value": "東京女子医科大学医学部消化器内科学"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-08-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006019165.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "KJ00006019165.pdf", "url": "https://twinkle.repo.nii.ac.jp/record/18881/files/KJ00006019165.pdf"}, "version_id": "4e65dab2-62da-438e-a326-1c22358c3949"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice"}]}, "item_type_id": "10001", "owner": "3", "path": ["1976"], "permalink_uri": "http://hdl.handle.net/10470/26180", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-08-10"}, "publish_date": "2010-08-10", "publish_status": "0", "recid": "18881", "relation": {}, "relation_version_is_last": true, "title": ["Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice"], "weko_shared_id": -1}
Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice
http://hdl.handle.net/10470/26180
http://hdl.handle.net/10470/26180d6672633-ab99-437d-8123-4f4fb24bba33
名前 / ファイル | ライセンス | アクション |
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KJ00006019165.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | マウス壊死性膵炎モデルにおけるIL-10投与効果の検討 | |||||
著者名 |
FUKUYA, Yuji
× FUKUYA, Yuji× NISHINO, Takayoshi× OYAMA, Hiroyasu× WATANABE, Shin-ichiro× HAYASHI, Naoaki |
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著者別名 | ||||||
姓名 | 福屋, 裕嗣 | |||||
著者別名 | ||||||
姓名 | 西野, 隆義 | |||||
著者別名 | ||||||
姓名 | 小山, 祐康 | |||||
著者別名 | ||||||
姓名 | 渡辺, 伸一郎 | |||||
著者別名 | ||||||
姓名 | 林, 直諒 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 73, 号 3/4, p. 78-87, 発行日 2003-04-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [目的]Interleukin-10 (IL-10)は抗炎症性サイトカインとして知られており,セルレイン(Cn)やコリンデフィシエントを用いた実験膵炎モデルでIL-10を投与することで膵炎が改善するという報告がある.今回我々は,セルレインおよび,リポポリサッカライド(LPS)を用いたマウス壊死性膵炎モデルを作製し,IL-10の投与効果を検討した.[方法]マウスにLPS 10mg/kg1回(Cn初回投与時)腹腔内投与+Cn 50μg/kg 1時間毎に計10回腹腔内投与して膵炎を作製し,IL-10 10,000 UをCnおよびLPS初回投与1時間前より2時間毎に計7回投与し,その投与効果を検討した.[結果](1)血清膵酵素上昇はCn初回投与時より12,24時間後でIL-10投与により抑制された.(2)膵組織学的にCn初回投与時より12,24時間後でIL-10投与により空胞形成や壊死が軽減した.(3)分子生物学的にCn初回投与時より3,6,12,24時間後でIL-10投与により膵組織中のTNFα,IL-1βmRNAの発現が抑制された.[結論]IL-10は実験壊死性膵炎において,TNFα,IL-1βの産生を抑制し,重症化を軽減させると考えられた. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interleukin-10 (IL-10) has recently been identified as a major anti-inflammatory cytokine, and there have been several reports that IL-10 administration reduces severe necrosis in cerulein- or choline deficient (CDE) -induced pancreatitis. We investigated the effect of IL-10 in a mouse model of acute necrotizing pancreatitis induced by ten intraperitoneal infusion of cerulein (50 μg/kg) at hourly intervals and a single intraperitoneal injection of LPS (10 mg/kg) concomitant with the first cerulein injection. The IL-10 treated group was also injected with 10,000 U of IL-10 seven times intraperitoneally every 2 h beginning 1 h before the cerulein infusion. The pancreas was examined for histological changes and analyzed for tissue TNFα mRNA and IL-1β mRNA by RT-PCR. Serum amylase and lipase release peaked at 12 h after the first cerulein injection, but their concentrations at 12 and 24 h were significantly reduced by IL-10. Histologically, acinar cell necrosis and vacuolization were dramatically attenuated at 12 and 24 h in the IL-10 treated group, and induction of tissue TNFα mRNA and IL-1β mRNA in the pancreas was significantly reduced by IL-10. In conclusion, IL-10 is capable of decreasing the severity of experimental acute necrotizing pancreatitis. Inhibition of TNFα and IL-1β production in the pancreas may explain the protective effect of IL-10. | |||||
著者所属 | ||||||
Department of Gastroenterology, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Clinical Laboratory Medicine, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Clinical Laboratory Medicine, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
東京女子医科大学医学部消化器内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部消化器内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部臨床検査科 | ||||||
著者所属 | ||||||
東京女子医科大学医学部臨床検査科 | ||||||
著者所属 | ||||||
東京女子医科大学医学部消化器内科学 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-10 | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNFα | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-Iβ | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | pancreatitis | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse |