{"created":"2023-06-20T16:59:43.370836+00:00","id":18881,"links":{},"metadata":{"_buckets":{"deposit":"241f4eb7-3309-4683-8f73-b20ee89517d5"},"_deposit":{"created_by":3,"id":"18881","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18881"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00018881","sets":["140:1307:1308:1974:1976"]},"author_link":["297653","297654","297656","297648","297657","297650","297652","297649","297651","297655"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウス壊死性膵炎モデルにおけるIL-10投与効果の検討"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"87","bibliographicPageStart":"78","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"FUKUYA, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHINO, Takayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OYAMA, Hiroyasu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WATANABE, Shin-ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Naoaki"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[目的]Interleukin-10 (IL-10)は抗炎症性サイトカインとして知られており,セルレイン(Cn)やコリンデフィシエントを用いた実験膵炎モデルでIL-10を投与することで膵炎が改善するという報告がある.今回我々は,セルレインおよび,リポポリサッカライド(LPS)を用いたマウス壊死性膵炎モデルを作製し,IL-10の投与効果を検討した.[方法]マウスにLPS 10mg/kg1回(Cn初回投与時)腹腔内投与+Cn 50μg/kg 1時間毎に計10回腹腔内投与して膵炎を作製し,IL-10 10,000 UをCnおよびLPS初回投与1時間前より2時間毎に計7回投与し,その投与効果を検討した.[結果](1)血清膵酵素上昇はCn初回投与時より12,24時間後でIL-10投与により抑制された.(2)膵組織学的にCn初回投与時より12,24時間後でIL-10投与により空胞形成や壊死が軽減した.(3)分子生物学的にCn初回投与時より3,6,12,24時間後でIL-10投与により膵組織中のTNFα,IL-1βmRNAの発現が抑制された.[結論]IL-10は実験壊死性膵炎において,TNFα,IL-1βの産生を抑制し,重症化を軽減させると考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"Interleukin-10 (IL-10) has recently been identified as a major anti-inflammatory cytokine, and there have been several reports that IL-10 administration reduces severe necrosis in cerulein- or choline deficient (CDE) -induced pancreatitis. We investigated the effect of IL-10 in a mouse model of acute necrotizing pancreatitis induced by ten intraperitoneal infusion of cerulein (50 μg/kg) at hourly intervals and a single intraperitoneal injection of LPS (10 mg/kg) concomitant with the first cerulein injection. The IL-10 treated group was also injected with 10,000 U of IL-10 seven times intraperitoneally every 2 h beginning 1 h before the cerulein infusion. The pancreas was examined for histological changes and analyzed for tissue TNFα mRNA and IL-1β mRNA by RT-PCR. Serum amylase and lipase release peaked at 12 h after the first cerulein injection, but their concentrations at 12 and 24 h were significantly reduced by IL-10. Histologically, acinar cell necrosis and vacuolization were dramatically attenuated at 12 and 24 h in the IL-10 treated group, and induction of tissue TNFα mRNA and IL-1β mRNA in the pancreas was significantly reduced by IL-10. In conclusion, IL-10 is capable of decreasing the severity of experimental acute necrotizing pancreatitis. Inhibition of TNFα and IL-1β production in the pancreas may explain the protective effect of IL-10.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"297653","nameIdentifierScheme":"WEKO"}],"names":[{"name":"福屋, 裕嗣"}]},{"nameIdentifiers":[{"nameIdentifier":"297654","nameIdentifierScheme":"WEKO"}],"names":[{"name":"西野, 隆義"}]},{"nameIdentifiers":[{"nameIdentifier":"297655","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小山, 祐康"}]},{"nameIdentifiers":[{"nameIdentifier":"297656","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渡辺, 伸一郎"}]},{"nameIdentifiers":[{"nameIdentifier":"297657","nameIdentifierScheme":"WEKO"}],"names":[{"name":"林, 直諒"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"IL-10","subitem_subject_scheme":"Other"},{"subitem_subject":"TNFα","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-Iβ","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Clinical Laboratory Medicine, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Clinical Laboratory Medicine, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"},{"subitem_text_value":"東京女子医科大学医学部臨床検査科"},{"subitem_text_value":"東京女子医科大学医学部臨床検査科"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006019165.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006019165.pdf","url":"https://twinkle.repo.nii.ac.jp/record/18881/files/KJ00006019165.pdf"},"version_id":"4e65dab2-62da-438e-a326-1c22358c3949"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice"}]},"item_type_id":"10001","owner":"3","path":["1976"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"18881","relation_version_is_last":true,"title":["Interleukin 10 Reduces the Severity of Acute Necrotizing Pancreatitis in Mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T20:57:51.016031+00:00"}