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HLA-DQ-RECOGNIZING CD4 CELL REQUIREMENT FOR GENERATING HEPATITIS B SURFACE ANTIGEN-SPECIFIC SUPPRESSOR T CELLS
http://hdl.handle.net/10470/24176
http://hdl.handle.net/10470/24176905b2ae4-4975-4c60-ad64-cb56aec1efb8
名前 / ファイル | ライセンス | アクション |
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KJ00006025284.pdf (577.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | HLA-DQ-RECOGNIZING CD4 CELL REQUIREMENT FOR GENERATING HEPATITIS B SURFACE ANTIGEN-SPECIFIC SUPPRESSOR T CELLS | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | HBs抗原特異的抑制性T細胞の誘導におけるHLA-DQ拘束性CD4陽性細胞の役割 | |||||
著者名 |
SUZUKI, Yoshiyuki
× SUZUKI, Yoshiyuki× YAMAUCHI, Katsumi× OBATA, Hiroshi× HAYASHI, Naoaki |
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著者別名 | ||||||
姓名 | 鈴木, 義之 | |||||
著者別名 | ||||||
姓名 | 山内, 克巳 | |||||
著者別名 | ||||||
姓名 | 小幡, 裕 | |||||
著者別名 | ||||||
姓名 | 林, 直諒 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 12, p. 983-989, 発行日 1997-12-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | HBs抗原に対する免疫学的寛容状態の解明のために我々はHBs抗原特異的抑制性T細胞の誘導のメカニズムについて検討を行った.抑制活性をみるための方法としては,我々がこれまでに報告してきたin vitroにおけるHBs抗体産生系を用いた.まず,HBワクチンで免疫されたhigh responder(HBワクチンに対する高応答者)より得られた末梢血単核球をhigh doseのHBs抗原で刺激し,CD8陽性の抑制性T細胞を誘導した.この抑制性T細胞はHBs抗原に特異的であり,HBs抗体の産生のみを抑制していた.さらにこのCD8陽性抑制性T細胞の誘導にはCD4陽性細胞が必要であり,in vitroにおいてCD4陽性細胞を除くことにより抑制性T細胞の誘導は阻害された.この抑制性T細胞を誘導するCD4陽性細胞(suppressor-inducer T cell)はHLA class 2抗原のDQ抗原に拘束されており,抑制性T細胞を誘導する培養液中に,anti-DQを加えることにより抑制性活性の低下が認められた.この活性の低下は,anti-DQにのみ引き起されるものでありanti-DRや,myeloma proteinでは抑制活性の低下は得られなかった.また,このanti-DQにより阻害されるのはCD4 suppreessor-inducer T cellを介したCD8 suppressor T cell誘導の系であり,抗体産生系の培養中にanti-DQを加えても同様の抑制活性の低下は得られなかった. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For a more precise analysis of the immunological tolerance to hepatitis B virus surface antigen (HBsAg), we studied the induction mechanisms of HBsAg-specific suppressor T cells (Ts). The stimulation of peripheral blood mononuclear cells (PBMC) obtained from HB vaccinees with a high dose of HBsAg resulted in the generation of HBsAg-specific Ts. While these activated Ts were CD8 cells, their induction was abrogated by the deletion of CD4 cells prior to the in vitro culture, indicating that CD4 T cells were needed to induce CD8 Ts. An in vitro inhibition study of Ts induction with monoclonal antibodies to major histocompatibility complex class 2 antigens revealed that the induction of Ts was inhibited by and-DQ but not by and-DR. However, anti-DQ inhibition dose not directly affect the suppressive effect of Ts, indicating that HLA-DQ antigen might be required only for the induction of Ts. From these results, we can assume that immune suppression is initiated by the stimulation of CD4 cells by a molecular complex composed of a fragment of HBsAg and HLA-DQ antigen that is expressed on the surface of antigen presenting cells. | |||||
著者所属 | ||||||
Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College:(Present office)Department of Gastroenterology, Toranomon Hospital | ||||||
著者所属 | ||||||
Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
東京女子医科大学消化器内科学:(現)虎の門病院消化器科 | ||||||
著者所属 | ||||||
東京女子医科大学消化器内科学 | ||||||
著者所属 | ||||||
東京女子医科大学消化器内科学 | ||||||
著者所属 | ||||||
東京女子医科大学消化器内科学 |