{"created":"2023-06-20T16:58:12.823906+00:00","id":16877,"links":{},"metadata":{"_buckets":{"deposit":"c500dc6b-dc2e-4250-b76d-cb4735354f0f"},"_deposit":{"created_by":3,"id":"16877","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16877"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016877","sets":["140:1307:1308:1912:1923"]},"author_link":["260908","260909","260911","260910","260913","260912","260907","260906"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"HBs抗原特異的抑制性T細胞の誘導におけるHLA-DQ拘束性CD4陽性細胞の役割"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"989","bibliographicPageStart":"983","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SUZUKI, Yoshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAUCHI, Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OBATA, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Naoaki"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HBs抗原に対する免疫学的寛容状態の解明のために我々はHBs抗原特異的抑制性T細胞の誘導のメカニズムについて検討を行った.抑制活性をみるための方法としては,我々がこれまでに報告してきたin vitroにおけるHBs抗体産生系を用いた.まず,HBワクチンで免疫されたhigh responder(HBワクチンに対する高応答者)より得られた末梢血単核球をhigh doseのHBs抗原で刺激し,CD8陽性の抑制性T細胞を誘導した.この抑制性T細胞はHBs抗原に特異的であり,HBs抗体の産生のみを抑制していた.さらにこのCD8陽性抑制性T細胞の誘導にはCD4陽性細胞が必要であり,in vitroにおいてCD4陽性細胞を除くことにより抑制性T細胞の誘導は阻害された.この抑制性T細胞を誘導するCD4陽性細胞(suppressor-inducer T cell)はHLA class 2抗原のDQ抗原に拘束されており,抑制性T細胞を誘導する培養液中に,anti-DQを加えることにより抑制性活性の低下が認められた.この活性の低下は,anti-DQにのみ引き起されるものでありanti-DRや,myeloma proteinでは抑制活性の低下は得られなかった.また,このanti-DQにより阻害されるのはCD4 suppreessor-inducer T cellを介したCD8 suppressor T cell誘導の系であり,抗体産生系の培養中にanti-DQを加えても同様の抑制活性の低下は得られなかった.","subitem_description_type":"Abstract"},{"subitem_description":"For a more precise analysis of the immunological tolerance to hepatitis B virus surface antigen (HBsAg), we studied the induction mechanisms of HBsAg-specific suppressor T cells (Ts). The stimulation of peripheral blood mononuclear cells (PBMC) obtained from HB vaccinees with a high dose of HBsAg resulted in the generation of HBsAg-specific Ts. While these activated Ts were CD8 cells, their induction was abrogated by the deletion of CD4 cells prior to the in vitro culture, indicating that CD4 T cells were needed to induce CD8 Ts. An in vitro inhibition study of Ts induction with monoclonal antibodies to major histocompatibility complex class 2 antigens revealed that the induction of Ts was inhibited by and-DQ but not by and-DR. However, anti-DQ inhibition dose not directly affect the suppressive effect of Ts, indicating that HLA-DQ antigen might be required only for the induction of Ts. From these results, we can assume that immune suppression is initiated by the stimulation of CD4 cells by a molecular complex composed of a fragment of HBsAg and HLA-DQ antigen that is expressed on the surface of antigen presenting cells.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"260910","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鈴木, 義之"}]},{"nameIdentifiers":[{"nameIdentifier":"260911","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山内, 克巳"}]},{"nameIdentifiers":[{"nameIdentifier":"260912","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小幡, 裕"}]},{"nameIdentifiers":[{"nameIdentifier":"260913","nameIdentifierScheme":"WEKO"}],"names":[{"name":"林, 直諒"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College:(Present office)Department of Gastroenterology, Toranomon Hospital"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"東京女子医科大学消化器内科学:(現)虎の門病院消化器科"},{"subitem_text_value":"東京女子医科大学消化器内科学"},{"subitem_text_value":"東京女子医科大学消化器内科学"},{"subitem_text_value":"東京女子医科大学消化器内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025284.pdf","filesize":[{"value":"577.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025284.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16877/files/KJ00006025284.pdf"},"version_id":"3f590e38-cb55-4d05-9470-f2b9b42b1269"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"HLA-DQ-RECOGNIZING CD4 CELL REQUIREMENT FOR GENERATING HEPATITIS B SURFACE ANTIGEN-SPECIFIC SUPPRESSOR T CELLS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HLA-DQ-RECOGNIZING CD4 CELL REQUIREMENT FOR GENERATING HEPATITIS B SURFACE ANTIGEN-SPECIFIC SUPPRESSOR T CELLS"}]},"item_type_id":"10001","owner":"3","path":["1923"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16877","relation_version_is_last":true,"title":["HLA-DQ-RECOGNIZING CD4 CELL REQUIREMENT FOR GENERATING HEPATITIS B SURFACE ANTIGEN-SPECIFIC SUPPRESSOR T CELLS"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:01:38.487141+00:00"}