{"_buckets": {"deposit": "6960ec53-d1f8-493c-a097-1634a693fb74"}, "_deposit": {"created_by": 3, "id": "20444", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "20444"}, "status": "published"}, "_oai": {"id": "oai:twinkle.repo.nii.ac.jp:00020444", "sets": ["2031"]}, "author_link": ["293833", "293820", "293825", "293826", "293830", "293824", "293834", "293823", "293829", "293827", "293832", "293831", "293821", "293835", "293822", "293828"], "item_10001_alternative_title_1": {"attribute_name": "別タイトル", "attribute_value_mlt": [{"subitem_alternative_title": "A Case of Adult Leigh\u0027s Disease With Multiple Sclerosis-Like Symptoms(Special Issue in Hornor of the Retirement of Professor Makoto Iwata at the Department of Neurology, Tokyo Women\u0027s Medical University)"}]}, "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-02-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "Extra", "bibliographicPageEnd": "E82", "bibliographicPageStart": "E75", "bibliographicVolumeNumber": "78", "bibliographic_titles": [{"bibliographic_title": "東京女子医科大学雑誌"}]}]}, "item_10001_creator_2": {"attribute_name": "著者名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "清水, 優子"}], "nameIdentifiers": [{"nameIdentifier": "293820", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "竹内, 恵"}], "nameIdentifiers": [{"nameIdentifier": "293821", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "太田, 宏平"}], "nameIdentifiers": [{"nameIdentifier": "293822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "永井, 知代子"}], "nameIdentifiers": [{"nameIdentifier": "293823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "吉澤, 浩志"}], "nameIdentifiers": [{"nameIdentifier": "293824", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "迫村, 泰成"}], "nameIdentifiers": [{"nameIdentifier": "293825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "内山, 真一郎"}], "nameIdentifiers": [{"nameIdentifier": "293826", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岩田, 誠"}], "nameIdentifiers": [{"nameIdentifier": "293827", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_date_25": {"attribute_name": "受付日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2010-08-10", "subitem_date_issued_type": "Created"}]}, "item_10001_description_34": {"attribute_name": "注記", "attribute_value_mlt": [{"subitem_description": "神経内科学教室岩田誠教授退任記念特別号", "subitem_description_type": "Other"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Leigh\u0027s disease (subacute necrotizing encephalomyelopathy) is a progressive neurological disorder caused by mitochondrial dysfunction that occurs primarily in infancy and childhood and only rarely in adulthood. We report a 40-year-old-woman, who had been diagnosed as having multiple sclerosis (MS) at age 38 after developing several episodes of transient diplopia, ataxia, and facial weakness on the right side. She was admitted to our hospital due to stupor, nystagmus, diplopia, and fever. Neurological findings included stupor, ataxic speech, nystagmus, diplopia on the right horizontal gaze, hyperreflexia on the dominant right side, bilateral extensor plantar responses, hypoesthesia on the left side of the face and extremities, hypermetria on the extremities, the presence of Romberg\u0027s sign, and ataxic gait. Brain MRI showed abnormal lesions in the peri-third ventricle, the periaqueductal gray matter of the midbrain, the hypothalamus, and the pontine tegmenta on the right side. The cerebrospinal fluid (CSF) contained 96 mg/dl protein and increased IgG. Serum and CSF lactic acid and pyruvate levels were increased. Aerobic testing was positive; muscle biopsy and mitochondrial DNA analysis were negative. ^\u003c123\u003eI-BMIPP myocardial images detected reduced uptake in the anterior-wall and apical portion. The myocardial biopsy revealed degeneration of myocardial fibers and mitochondrial abnormalities, such as increased size and abnormal inclusions. Therefore, adult Leigh\u0027s disease was diagnosed. The patient died unexpectedly due to acute respiratory failure at age 42. An autopsy was not performed. In patients with MS-like symptoms and MRI findings in the midbrain, brain stem, and basal ganglia, the possibility of adult Leigh\u0027s disease should be considered.", "subitem_description_type": "Abstract"}]}, "item_10001_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "293828", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "SHIMIZU, Yuko"}]}, {"nameIdentifiers": [{"nameIdentifier": "293829", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "TAKEUCHI, Megumi"}]}, {"nameIdentifiers": [{"nameIdentifier": "293830", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "OTA, Kohei"}]}, {"nameIdentifiers": [{"nameIdentifier": "293831", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "NAGAI, Chiyoko"}]}, {"nameIdentifiers": [{"nameIdentifier": "293832", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "YOSHIZAWA, Hiroshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "293833", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "SAKOMURA, Yasunari"}]}, {"nameIdentifiers": [{"nameIdentifier": "293834", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "UCHIYAMA, Shinichiro"}]}, {"nameIdentifiers": [{"nameIdentifier": "293835", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "IWATA, Makoto"}]}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "東京女子医科大学学会"}]}, "item_10001_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00161368", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0040-9022", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_subject_47": {"attribute_name": "著者キーワード", "attribute_value_mlt": [{"subitem_subject": "adult Leigh\u0027s disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "multiple sclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "midbrain", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myocardiac biopsy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mitochondria", "subitem_subject_scheme": "Other"}]}, "item_10001_text_35": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "東京女子医科大学医学部神経内科学"}, {"subitem_text_value": "東京女子医科大学医学部神経内科学"}, {"subitem_text_value": "東京理科大学理学部"}, {"subitem_text_value": "東京女子医科大学医学部神経内科学"}, {"subitem_text_value": "東京女子医科大学医学部神経内科学"}, {"subitem_text_value": "東京女子医科大学医学部循環器内科学"}, {"subitem_text_value": "東京女子医科大学医学部神経内科学"}, {"subitem_text_value": "東京女子医科大学医学部神経内科学"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-08-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006015118.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "KJ00006015118.pdf", "url": "https://twinkle.repo.nii.ac.jp/record/20444/files/KJ00006015118.pdf"}, "version_id": "b83d646a-d70a-4b34-93bc-62e181a822c2"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "多発性硬化症様症状を呈した成人型Leigh脳症(神経内科学教室岩田誠教授退任記念特別号)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "多発性硬化症様症状を呈した成人型Leigh脳症(神経内科学教室岩田誠教授退任記念特別号)"}]}, "item_type_id": "10001", "owner": "3", "path": ["2031"], "permalink_uri": "http://hdl.handle.net/10470/27743", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-08-10"}, "publish_date": "2010-08-10", "publish_status": "0", "recid": "20444", "relation": {}, "relation_version_is_last": true, "title": ["多発性硬化症様症状を呈した成人型Leigh脳症(神経内科学教室岩田誠教授退任記念特別号)"], "weko_shared_id": 3}