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Polymorphisms of β-Adrenergic Receptor Gene Appears to Be a Genetic Risk Factor for Obesity in Preschool Children with Partial Growth Hormone Deficiency(Papers for cerebrating the Forty Aniversary of the Department of Pediatrics, Tokyo Women's Medical University Center East)
http://hdl.handle.net/10470/27460
http://hdl.handle.net/10470/27460aa0d3eee-5204-4065-9080-10b29e4fbbff
名前 / ファイル | ライセンス | アクション |
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KJ00006017912.pdf (589.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | Polymorphisms of β-Adrenergic Receptor Gene Appears to Be a Genetic Risk Factor for Obesity in Preschool Children with Partial Growth Hormone Deficiency(Papers for cerebrating the Forty Aniversary of the Department of Pediatrics, Tokyo Women's Medical University Center East) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | 部分型成長ホルモン分泌不全を伴う乳幼児肥満の原因としてのβアドレナリン受容体遺伝子多型(東京女子医科大学東医療センター小児科開局40周年記念論文集) | |||||
著者名 |
MATSUOKA, Hisafumi
× MATSUOKA, Hisafumi× IWAMA, Saika× MIURA, Naoko× SUGAWARA, Hisae× IKEZAKI, Ayako× SUGIHARA, Shigetaka |
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著者別名 | ||||||
姓名 | 松岡, 尚史 | |||||
著者別名 | ||||||
姓名 | 岩間, 彩香 | |||||
著者別名 | ||||||
姓名 | 三浦, 直子 | |||||
著者別名 | ||||||
姓名 | 菅原, 久江 | |||||
著者別名 | ||||||
姓名 | 池﨑, 綾子 | |||||
著者別名 | ||||||
姓名 | 杉原, 茂孝 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 77, 号 Extra, p. E54-E59, 発行日 2007-05-31 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 成人領域では,肥満に影響を及ぼす様々な遺伝子多型が近年発見され,βアドレナリン受容体もその1つである.今回,東医療センター小児科に成長ホルモン治療のため通院している男児27人,女子19人を対象として,1~6歳までの身体所見(身長,体重)縦断的データをβ2,3アドレナリン両遺伝子多型群間で比較検討を行った.日本人に多いとされるβ3アドレナリン受容体遺伝子コドン64の変異群では,非変異群と比較して6歳時までの肥満度(%)が+17.7対+1.3と有意に大きく推移していた.β2コドン16では同様の遺伝子変異による差を認めなかった.就学前という低年齢時より肥満度の差を呈していることから,β3アドレナリン受容体遺伝子多型は本邦における小児肥満の原因の1つであることが示唆された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Over the last years, several single nucleotide polymorphisms influencing early-onset obesity have been characterized. As candidate genes, recent studies have focused on the adrenergic receptor system. A descriptive study using the medical charts of 46 children (19 girls and 27 boys) were of short stature and treated by growth hormone (GH). Anthropometric data of the children were recorded longitudinally from 1 to 6 years of age prior to the commencement of GH treatment. The mean percent overweight increased linearly during the 5-year study period, from -5.3% to 17.7% in the group of children with the mutation of the β3-adrenergic receptor codon 64 polymorphism, and -5.0% to 1.3% in those without this mutation. In contrast, the differences among the subtypes of the β2-adrenergic receptor gene codon 16 polymorphism did not attain statistical significance at any time point during this study. Trp64Arg polymorphism of the β3-adrenergic receptor gene appears to be a genetic risk factor for obesity in Japanese preschool children. | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 東京女子医科大学東医療センター小児科開局40周年記念論文集 | |||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University Medical Center East | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University Medical Center East | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University Medical Center East | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University Medical Center East | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University Medical Center East | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University Medical Center East | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター小児科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター小児科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター小児科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター小児科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター小児科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター小児科 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | β-adrenergic receptor gene | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth hormone | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | obesity | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | preschool children |