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We studied ten patients who had been treated at the Department of Nephrology, Tokyo Metropolitan Komagome Hospital, between January 1999 and August 2004. All the patients were generally treated with oral steroids (predonisolone, 0.8 mg/kgBW, daily). Three patients received maintenance hemodialysis (HD) treatment but the remaining 7 patients did not. The former patients were designated as the HD group, and the latter patients were designated as the non-HD group. The change in the serum creatinine (Cr) value was calculated each day in every patient. The daily serum Cr increase in the HD groupwas 0.64 ± 0.26 mg/dl, which was significantly higher than that in the non-HD group (0.05 ± 0.07 mg/dl; p\u003c 0.01). 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MPO-ANCA型一次性急速進行性糸球体腎炎における腎機能予後と血清クレアチニン上昇速度の関係
http://hdl.handle.net/10470/26919
http://hdl.handle.net/10470/269192c4ea56e-4c8a-4d0c-b969-133fd7644515
名前 / ファイル | ライセンス | アクション |
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KJ00006018485.pdf (620.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | MPO-ANCA型一次性急速進行性糸球体腎炎における腎機能予後と血清クレアチニン上昇速度の関係 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Daily Increase of Serum Creatinine Levels is Involved in Renal Outcome in Primary MPO-ANCA Positive Rapidly Progressive Glomerulonephritis | |||||
著者名 |
中村, 裕也
× 中村, 裕也× 安藤, 稔× 齋藤, 博 |
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著者別名 | ||||||
姓名 | NAKAMURA, Yuya | |||||
著者別名 | ||||||
姓名 | ANDO, Minoru | |||||
著者別名 | ||||||
姓名 | SAITO, Hiroshi | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 75, 号 7/8, p. 196-201, 発行日 2005-08 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To determine a clinical marker associated with renal outcome in patients with myeloperoxidaseantineutrophil cytoplasmic antibody (MPO-ANCA)-positive primary rapidly progressive glomerulonephritis (RPGN), clinical data were retrospectively reviewed. We studied ten patients who had been treated at the Department of Nephrology, Tokyo Metropolitan Komagome Hospital, between January 1999 and August 2004. All the patients were generally treated with oral steroids (predonisolone, 0.8 mg/kgBW, daily). Three patients received maintenance hemodialysis (HD) treatment but the remaining 7 patients did not. The former patients were designated as the HD group, and the latter patients were designated as the non-HD group. The change in the serum creatinine (Cr) value was calculated each day in every patient. The daily serum Cr increase in the HD groupwas 0.64 ± 0.26 mg/dl, which was significantly higher than that in the non-HD group (0.05 ± 0.07 mg/dl; p< 0.01). Consequently, the serum Cr levels at the initiation of OS treatment and the maximum levels of serum Cr during the patients' clinical courses were significantly higher in the HD group (9.1 ± 2.2 mg/dl and 10.1 ± 1.9 mg/dl, respectively; p<0.0l) than in the non-HD group (3.5 ± 1.4 mg/dl and 3.9 ± 1.6 mg/dl, respectively; p<0.0l). In addition, the "clinical scores for disease severity", which was comprehensively developed to assess the prognosis of RPGN patients, was significantly higher in the HD group (7.0 ± 0.0 versus 4.0 ± 5.1; p<0.01). In conclusion, this study suggests that a high daily increase in serum Cr (over 0.6 mg/dl) may reflect poor renal survival in MPO-ANCA-positive primary RPGN patients. The daily increase in serum Cr levels may effectively reflect the dynamism of renal function in MPO-ANCA-positive primary RPGN patients and may be useful for assessing the efficacy of treatment. | |||||
著者所属 | ||||||
東京都立駒込病院腎臓内科 | ||||||
著者所属 | ||||||
東京都立駒込病院腎臓内科:東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京都立駒込病院腎臓内科 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | daily increase in serum creatinine | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | maximum levels of serum creatinine | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | clinical scores for disease severity | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | scores for pathological stage |