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  1. A 資料種別
  2. 010 東京女子医科大学雑誌
  3. 010A 論文
  4. 66巻
  5. 12号

解離性大動脈瘤における凝血学的検討

http://hdl.handle.net/10470/23677
http://hdl.handle.net/10470/23677
a3550487-034b-4daa-bd2b-104a087eb196
名前 / ファイル ライセンス アクション
KJ00006025927.pdf KJ00006025927.pdf (964.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-08-10
タイトル
タイトル 解離性大動脈瘤における凝血学的検討
言語
言語 jpn
資源タイプ
資源タイプ journal article
別タイトル
その他のタイトル Analysis of Coagulopathy in Patients with Dissecting Aortic Aneurysm
著者名 佐藤, 加代子

× 佐藤, 加代子

WEKO 259405

佐藤, 加代子

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著者別名
姓名 SATO, Kayoko
出版者
出版者 東京女子医科大学学会
受付日付
ISSN
収録物識別子タイプ ISSN
収録物識別子 0040-9022
NCID
収録物識別子タイプ NCID
収録物識別子 AN00161368
書誌情報 東京女子医科大学雑誌

巻 66, 号 12, p. 1045-1054, 発行日 1996-12-25
著者版フラグ
抄録
内容記述タイプ Abstract
内容記述 When deciding on the method of treatment for patients with dissecting aortic aneurysm (DA), the following factors should be taken into consideration: the duration of disease, the diameter of the aneurysm, and whether the pseudolumen is thrombosed. Coagulation and fiblolytic activity were investigated in the acute phase (1-14 days from the onset), subacute phase (15-56 days), and chronic phase (>57 days) of DA, and the aneurysms were classified as thrombosed type (type T) or open communicated type (type O). Eighty-six patients (56 men and 30 women) with DA were studied. Twenty-three patients had DeBakey type I aneurysms, while 4 had type II, 7 had type Ilia, and 52 had type Illb. Thirty-five patients had type T disease and 51 had type O. We measured thrombin-antithrombin III complex (TAT), prothrombin fragment 1+2 (F_<1+2>), tissue plasminogen activator (t-PA), plasminogen activator inhibitor activity (PAIact), D-dimer, β-thromboglobulin (β-TG), and platelet factor 4 (PF4) levels. All patients with DA showed secondary hypercoagulability and hyperfibrinolysis in the acute phase, so they were recognized to be in a pre-DIC state. Type T patients showed hypercoagulability and the onset of thrombus formation in the dilated pseudolumen was suggested to occur in early acute phase due to elevated TAT and β-TG levels. Type O patients showed increased secondary fibrinolysis, because D-dimer levels were higher than in type T patients during each phase. The maximum aneurysm diameter and changes of coagulation parameters were correlated positively in type T patients during the acute and chronic phases, and in type O patients during the acute phase, so these patients were recognized to be in the pre-DIC state. No significant changes were seen in coagulation parameters between the preoperative and postoperative periods in both types of DA, probably due to the effect of graft inplantation and residual dissection of the aorta. This study suggested that mesurement of coagulation parameters may be useful in distinguishing type T and type O aneurysm, and may help to decide on the treatment of DA.
著者所属
東京女子医科大学循環器内科学教室
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