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消化器癌におけるCOX-2発現:発癌予防,治療の標的として(2) : 胃癌とCOX-2
http://hdl.handle.net/10470/27636
http://hdl.handle.net/10470/2763610467101-7c1b-49ea-a947-e1d11adef637
名前 / ファイル | ライセンス | アクション |
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KJ00006017944.pdf (768.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 消化器癌におけるCOX-2発現:発癌予防,治療の標的として(2) : 胃癌とCOX-2 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Expression of COX-2 in Gastrointestinal Cancer: As a Target for Cancer Prevention and Therapy (2) : Gastric Cancer and COX-2 | |||||
著者名 |
吉松, 和彦
× 吉松, 和彦× 小川, 健治 |
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著者別名 | ||||||
姓名 | YOSHIMATSU, Kazuhiko | |||||
著者別名 | ||||||
姓名 | OGAWA, Kenji | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 77, 号 11, p. 547-552, 発行日 2007-11 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent studies have demonstrated that increased amount of prostaglandin E_2 (PGE_2) produced by overexpression of cyclooxygenase-2 (COX-2)/microsomal PGE synthase-1 (mPGES-1) is involved in tumor proliferation. In addition, relationships with the epidermal growth factor (EGF)/mitogen activated protein (MAP) kinase signal pathway related to cell proliferation and Akt/protein kinase B (PKB) related to resistance of apoptosis are being clarified. Association of COX-2 with gastric cancer has not been established as clearly as in colon cancer. However, increased expression of COX-2 in gastric cancer was confirmed, and in cell culture or animal models, influence of COX-2 on tumor proliferation was indicated. Thus, the usefulness of COX-2 inhibitor in treatment has been demonstrated. However, in precancerous lesions of gastric cancer, COX-2 expression is controversial and the usefulness of COX-2 inhibitor has not been demonstrated. Further studies about COX-2 and gastric cancer including clinical trials are needed and also more studies should be performed about other PGE_2 related molecules as well as COX-2. | |||||
著者所属 | ||||||
東京女子医科大学東医療センター外科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター外科 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastric cancer | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclooxygenase-2 | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | prostaglandin E_2 | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | COX-2 inhibitors |