{"created":"2023-06-20T17:00:48.240791+00:00","id":20337,"links":{},"metadata":{"_buckets":{"deposit":"f1f6877f-2327-4ed6-9907-78306fa1dcfb"},"_deposit":{"created_by":3,"id":"20337","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20337"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00020337","sets":["140:1307:1308:2014:2027"]},"author_link":["296882","296881","296880","296879"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Expression of COX-2 in Gastrointestinal Cancer: As a Target for Cancer Prevention and Therapy (2) : Gastric Cancer and COX-2"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"552","bibliographicPageStart":"547","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉松, 和彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 健治"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent studies have demonstrated that increased amount of prostaglandin E_2 (PGE_2) produced by overexpression of cyclooxygenase-2 (COX-2)/microsomal PGE synthase-1 (mPGES-1) is involved in tumor proliferation. In addition, relationships with the epidermal growth factor (EGF)/mitogen activated protein (MAP) kinase signal pathway related to cell proliferation and Akt/protein kinase B (PKB) related to resistance of apoptosis are being clarified. Association of COX-2 with gastric cancer has not been established as clearly as in colon cancer. However, increased expression of COX-2 in gastric cancer was confirmed, and in cell culture or animal models, influence of COX-2 on tumor proliferation was indicated. Thus, the usefulness of COX-2 inhibitor in treatment has been demonstrated. However, in precancerous lesions of gastric cancer, COX-2 expression is controversial and the usefulness of COX-2 inhibitor has not been demonstrated. Further studies about COX-2 and gastric cancer including clinical trials are needed and also more studies should be performed about other PGE_2 related molecules as well as COX-2.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"296881","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YOSHIMATSU, Kazuhiko"}]},{"nameIdentifiers":[{"nameIdentifier":"296882","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OGAWA, Kenji"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"gastric cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclooxygenase-2","subitem_subject_scheme":"Other"},{"subitem_subject":"prostaglandin E_2","subitem_subject_scheme":"Other"},{"subitem_subject":"COX-2 inhibitors","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学東医療センター外科"},{"subitem_text_value":"東京女子医科大学東医療センター外科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006017944.pdf","filesize":[{"value":"768.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006017944.pdf","url":"https://twinkle.repo.nii.ac.jp/record/20337/files/KJ00006017944.pdf"},"version_id":"49a08cb7-9f00-4d84-bc1e-f2b50f28773e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"消化器癌におけるCOX-2発現:発癌予防,治療の標的として(2) : 胃癌とCOX-2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"消化器癌におけるCOX-2発現:発癌予防,治療の標的として(2) : 胃癌とCOX-2"}]},"item_type_id":"10001","owner":"3","path":["2027"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"20337","relation_version_is_last":true,"title":["消化器癌におけるCOX-2発現:発癌予防,治療の標的として(2) : 胃癌とCOX-2"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T20:59:04.887032+00:00"}