WEKO3
アイテム
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Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae-Derived Mitogen (SDM)
http://hdl.handle.net/10470/26176
http://hdl.handle.net/10470/261769ee193ed-362e-4d6d-8531-f275c215bdd7
名前 / ファイル | ライセンス | アクション |
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KJ00006019166.pdf (844.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae-Derived Mitogen (SDM) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Streptococcus dysgalactiae由来マイトジェン(SDM)のウシT細胞に対するスーパー抗原活性の検討 | |||||
著者名 |
MONZE, Mwaka
× MONZE, Mwaka× KATO, Hidehito× HAYASHI, Tomohito× ABE, Ryo× MIYOSHI-AKIYAMA, Tohru× UCHIYAMA, Takehiko× IMANISHI, Ken'ichi |
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著者別名 | ||||||
姓名 | モンゼ, ムワカ | |||||
著者別名 | ||||||
姓名 | 加藤, 秀人 | |||||
著者別名 | ||||||
姓名 | 林, 智人 | |||||
著者別名 | ||||||
姓名 | 安部, 良 | |||||
著者別名 | ||||||
姓名 | 三好(秋山), 徹 | |||||
著者別名 | ||||||
姓名 | 内山, 竹彦 | |||||
著者別名 | ||||||
姓名 | 今西, 健一 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 73, 号 3/4, p. 88-98, 発行日 2003-04-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Streptococcus dysgalactiae由来マイトジェン(SDM)は近年,当教室でウシ由来菌株S. dysgalactiaeより精製され,ヒトT細胞に対してスーパー抗原活性を示す物質である.SDMがウシ由来菌株より得られた物質であることから,ヒトよりウシT細胞に強く働くスーパー抗原であることを予測し,実験を行った.SDMはウシ末梢血中のT細胞の細胞増殖を誘導した.ヒトではT細胞レセプター(TCR)にVβ1あるいはVβ23を持つT細胞を活性化する.SDMはこれらのVβに類似した構造を持つウシのVβBTB18陽性T細胞を活性化した.以上により,SDMはウシT細胞に対してスーパー抗原活性を示すことが明らかになった.SDMのスーパー抗原活性をヒトに病原性を示すS. pyogenesが産生するスーパー抗原SpeCと比較した.SDMにはウシ末梢血が,SpeCにはヒト末梢血がより強い細胞増殖反応を示した.SDMはウシのS. dysgalactiae感染症において病原因子としてより大きな役割を持つことが示唆された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Streptococcus dysgalactiae-derived mitogen (SDM) was recently identified from a bovine isolate of S. dysgalactiae. A comparison of its effects on human and bovine PBMC revealed that it acts as a superantigen on both species, stimulating the T cell fraction of PBMC to proliferate. It selectively targets human Vβ1 and Vβ23 positive T cells and reactive bovine T cells express the bovine TCR-Vβ chain most similar to these human targets, VβBTB18. The superantigen SpeC, which is a product of the predominantly human pathogen Streptococcus pyogenes, also activates corresponding T cells in human and bovine systems. SDM however, has a much more potent effect on bovine cells than human cells and is more likely to have a pathogenic role in S. dysgalactiae infections of cows than humans. | |||||
著者所属 | ||||||
Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Division of Immunobiology, Research Institute, Tokyo University of Science | ||||||
著者所属 | ||||||
Division of Immunobiology, Research Institute, Tokyo University of Science | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学 | ||||||
著者所属 | ||||||
東京理科大学生命科学研究所免疫生物学研究部門 | ||||||
著者所属 | ||||||
東京理科大学生命科学研究所免疫生物学研究部門 | ||||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | superantigen | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | bovine | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cell | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | streptococcus |