{"created":"2023-06-20T16:59:43.190866+00:00","id":18877,"links":{},"metadata":{"_buckets":{"deposit":"eee2e96a-b5fe-46bb-84dc-1908626b5660"},"_deposit":{"created_by":3,"id":"18877","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18877"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00018877","sets":["140:1307:1308:1974:1976"]},"author_link":["300676","300667","300674","300679","300678","300675","300677","300671","300670","300669","300672","300673","300680","300668"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Streptococcus dysgalactiae由来マイトジェン(SDM)のウシT細胞に対するスーパー抗原活性の検討"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"98","bibliographicPageStart":"88","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MONZE, Mwaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATO, Hidehito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Tomohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ABE, Ryo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIYOSHI-AKIYAMA, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UCHIYAMA, Takehiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMANISHI, Ken'ichi"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Streptococcus dysgalactiae由来マイトジェン(SDM)は近年,当教室でウシ由来菌株S. dysgalactiaeより精製され,ヒトT細胞に対してスーパー抗原活性を示す物質である.SDMがウシ由来菌株より得られた物質であることから,ヒトよりウシT細胞に強く働くスーパー抗原であることを予測し,実験を行った.SDMはウシ末梢血中のT細胞の細胞増殖を誘導した.ヒトではT細胞レセプター(TCR)にVβ1あるいはVβ23を持つT細胞を活性化する.SDMはこれらのVβに類似した構造を持つウシのVβBTB18陽性T細胞を活性化した.以上により,SDMはウシT細胞に対してスーパー抗原活性を示すことが明らかになった.SDMのスーパー抗原活性をヒトに病原性を示すS. pyogenesが産生するスーパー抗原SpeCと比較した.SDMにはウシ末梢血が,SpeCにはヒト末梢血がより強い細胞増殖反応を示した.SDMはウシのS. dysgalactiae感染症において病原因子としてより大きな役割を持つことが示唆された.","subitem_description_type":"Abstract"},{"subitem_description":"Streptococcus dysgalactiae-derived mitogen (SDM) was recently identified from a bovine isolate of S. dysgalactiae. A comparison of its effects on human and bovine PBMC revealed that it acts as a superantigen on both species, stimulating the T cell fraction of PBMC to proliferate. It selectively targets human Vβ1 and Vβ23 positive T cells and reactive bovine T cells express the bovine TCR-Vβ chain most similar to these human targets, VβBTB18. The superantigen SpeC, which is a product of the predominantly human pathogen Streptococcus pyogenes, also activates corresponding T cells in human and bovine systems. SDM however, has a much more potent effect on bovine cells than human cells and is more likely to have a pathogenic role in S. dysgalactiae infections of cows than humans.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"300674","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モンゼ, ムワカ"}]},{"nameIdentifiers":[{"nameIdentifier":"300675","nameIdentifierScheme":"WEKO"}],"names":[{"name":"加藤, 秀人"}]},{"nameIdentifiers":[{"nameIdentifier":"300676","nameIdentifierScheme":"WEKO"}],"names":[{"name":"林, 智人"}]},{"nameIdentifiers":[{"nameIdentifier":"300677","nameIdentifierScheme":"WEKO"}],"names":[{"name":"安部, 良"}]},{"nameIdentifiers":[{"nameIdentifier":"300678","nameIdentifierScheme":"WEKO"}],"names":[{"name":"三好(秋山), 徹"}]},{"nameIdentifiers":[{"nameIdentifier":"300679","nameIdentifierScheme":"WEKO"}],"names":[{"name":"内山, 竹彦"}]},{"nameIdentifiers":[{"nameIdentifier":"300680","nameIdentifierScheme":"WEKO"}],"names":[{"name":"今西, 健一"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"superantigen","subitem_subject_scheme":"Other"},{"subitem_subject":"bovine","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"streptococcus","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Division of Immunobiology, Research Institute, Tokyo University of Science"},{"subitem_text_value":"Division of Immunobiology, Research Institute, Tokyo University of Science"},{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"東京女子医科大学医学部微生物学免疫学"},{"subitem_text_value":"東京女子医科大学医学部微生物学免疫学"},{"subitem_text_value":"東京理科大学生命科学研究所免疫生物学研究部門"},{"subitem_text_value":"東京理科大学生命科学研究所免疫生物学研究部門"},{"subitem_text_value":"東京女子医科大学医学部微生物学免疫学"},{"subitem_text_value":"東京女子医科大学医学部微生物学免疫学"},{"subitem_text_value":"東京女子医科大学医学部微生物学免疫学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006019166.pdf","filesize":[{"value":"844.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006019166.pdf","url":"https://twinkle.repo.nii.ac.jp/record/18877/files/KJ00006019166.pdf"},"version_id":"f41a60d2-f99b-460a-a78b-324fc786f587"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae-Derived Mitogen (SDM)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae-Derived Mitogen (SDM)"}]},"item_type_id":"10001","owner":"3","path":["1976"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"18877","relation_version_is_last":true,"title":["Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae-Derived Mitogen (SDM)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T20:52:27.276254+00:00"}