{"created":"2023-06-20T17:00:54.831566+00:00","id":20466,"links":{},"metadata":{"_buckets":{"deposit":"81f9efe7-efa4-4965-afe6-03cc996c11a9"},"_deposit":{"created_by":3,"id":"20466","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20466"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00020466","sets":["140:1307:1308:2029:2031"]},"author_link":["294198","294203","294210","294216","294204","294196","294214","294195","294209","294199","294208","294212","294211","294205","294215","294206","294197","294201","294202","294207","294200","294213"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Expression of Tissue Factor in Atherosclerotic Plaques of Carotid Arteries(Special Issue in Hornor of the Retirement of Professor Makoto Iwata at the Department of Neurology, Tokyo Women's Medical University)"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-02-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Extra","bibliographicPageEnd":"E159","bibliographicPageStart":"E154","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"遠井, 素乃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴田, 亮行"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内山, 真一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡田, 芳和"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川俣, 貴一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川島, 明次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加藤, 陽一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤田, 達男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小林, 槇雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宇羽野, 惠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩田, 誠"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_34":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"神経内科学教室岩田誠教授退任記念特別号","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Emerging evidence suggests that plaque destabilization based on persistent inflammation in carotid atherosclerosis (CAS) plays a critical role in cerebral infarction. Tissue factor (TF) acts as a membrane-bound receptor for activated factor VII triggering proinflammatory cell signaling. The aim of the present study was to determine the involvement of TF in destabilization of CAS plaques. This study was carried out on carotid endarterectomy specimens obtained from twenty CAS patients. The specimens were processed for making 30% sucroseimmersed, optimal cutting temperature (OCT) compound-embedded frozen sections and freshly frozen materials; the former was used for immunohistochemistry, and the latter for immunoblotting. The primary antibodies were mouse monoclonal IgG_1 against TF, CD68, α-smooth muscle actin (SMA), and β-actin. Immunoreaction on sections was visualized by the avidin-biotin-immunoperoxidase complex method, and that on blots was detected by the chemiilluminescence method. TF immunoreactivity was localized to endothelial cells, CD 68-immunoreactive macrophages, and SMA-immunoreactive smooth muscle cells, and it was prominent in macrophage-rich plaques (MRPs) compared with macrophage-poor plaques (MPPs). The immunoreactive density for TF normalized with β-actin was significantly increased in the MRP group compared with the MPP group. Our results suggest that TF participates in destabilization of CAS plaques, by its expression in the lesional cells.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"294206","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TOI, Sono"}]},{"nameIdentifiers":[{"nameIdentifier":"294207","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SHIBATA, Noriyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"294208","nameIdentifierScheme":"WEKO"}],"names":[{"name":"UCHIYAMA, Shinichiro"}]},{"nameIdentifiers":[{"nameIdentifier":"294209","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OKADA, Yoshikazu"}]},{"nameIdentifiers":[{"nameIdentifier":"294210","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAWAMATA, Takakazu"}]},{"nameIdentifiers":[{"nameIdentifier":"294211","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAWASHIMA, Akitsugu"}]},{"nameIdentifiers":[{"nameIdentifier":"294212","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KATO, Yoichiro"}]},{"nameIdentifiers":[{"nameIdentifier":"294213","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SAWADA, Tatsuo"}]},{"nameIdentifiers":[{"nameIdentifier":"294214","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KOBAYASHI, Makio"}]},{"nameIdentifiers":[{"nameIdentifier":"294215","nameIdentifierScheme":"WEKO"}],"names":[{"name":"UBANO, Megumi"}]},{"nameIdentifiers":[{"nameIdentifier":"294216","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IWATA, Makoto"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"atherosclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"carotid artery","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue factor","subitem_subject_scheme":"Other"},{"subitem_subject":"plaque instability","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学医学部神経内科学"},{"subitem_text_value":"東京女子医科大学医学部第一病理学"},{"subitem_text_value":"東京女子医科大学医学部神経内科学"},{"subitem_text_value":"東京女子医科大学医学部脳神経外科学"},{"subitem_text_value":"東京女子医科大学附属八千代医療センター脳神経外科"},{"subitem_text_value":"東京女子医科大学医学部脳神経外科学"},{"subitem_text_value":"東京女子医科大学医学部第一病理学"},{"subitem_text_value":"東京女子医科大学医学部第一病理学"},{"subitem_text_value":"東京女子医科大学医学部第一病理学"},{"subitem_text_value":"東京女子医科大学医学部神経内科学"},{"subitem_text_value":"東京女子医科大学医学部神経内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006015132.pdf","filesize":[{"value":"606.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006015132.pdf","url":"https://twinkle.repo.nii.ac.jp/record/20466/files/KJ00006015132.pdf"},"version_id":"ceec14b3-391e-4cd3-af72-aef1c33fdec2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"頸動脈アテローム硬化プラークにおける組織因子の発現(神経内科学教室岩田誠教授退任記念特別号)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"頸動脈アテローム硬化プラークにおける組織因子の発現(神経内科学教室岩田誠教授退任記念特別号)"}]},"item_type_id":"10001","owner":"3","path":["2031"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"20466","relation_version_is_last":true,"title":["頸動脈アテローム硬化プラークにおける組織因子の発現(神経内科学教室岩田誠教授退任記念特別号)"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:57:15.459401+00:00"}