{"created":"2023-06-20T17:00:53.012391+00:00","id":20426,"links":{},"metadata":{"_buckets":{"deposit":"2977655e-2f1d-4081-88d4-24fecce91715"},"_deposit":{"created_by":3,"id":"20426","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20426"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00020426","sets":["140:1307:1308:2029:2030"]},"author_link":["294101","294100","294102","294097","294095","294099","294094","294103","294098","294096"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regulation of Oncogene c-maf Expression in the Kidney under Oxidative Stress"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"17","bibliographicPageStart":"10","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大石, 哲也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"芳田, 工"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉浦, 秀和"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土谷, 健"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"新田, 孝作"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Maf is a family of oncogenes that encode a transcription factors containing a typical bZip structure -a motif for protein dimerization and DNA binding- and have been speculated to possess various potentials in mediating development, cellular differentiation and biological activities in several organs. Previously, we reported that c-maf modulates the antioxidative pathway via plasma glutathione peroxidase-3 in the proximal tubules of the mouse kidney. Therefore, we suggested that c-maf might play an important role in the presence of oxidative stress in the kidney. Here, we investigated c-maf expression in a rat model for renal ischemia reperfusion injury and cultured cells derived from human kidney proximal tubular cells (HK-2) treated with several oxidative compounds. The in vivo and in vitro experiments demonstrated that the expression of c-maf mRNA was relatively low during the early stage of oxidative stress but increased at a later stage. An immunohistochemical study showed a reduction in c-maf protein over a similar time course. Tunel staining in HK-2 cells that were overexpressing c-maf showed a tendency toward a protective effect against H_2O_2, and the expression of the c-maf gene was related to a decrease in p21 and p53. These data indicate that c-maf depletion may trigger apoptotic cell death under stressful conditions, suggesting that the c-maf gene may be related to anti-stress related genes.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"294099","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OISHI, Tetsuya"}]},{"nameIdentifiers":[{"nameIdentifier":"294100","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YOSHIDA, Takumi"}]},{"nameIdentifiers":[{"nameIdentifier":"294101","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SUGIURA, Hidekazu"}]},{"nameIdentifiers":[{"nameIdentifier":"294102","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TSUCHIYA, Ken"}]},{"nameIdentifiers":[{"nameIdentifier":"294103","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NITTA, Kosaku"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"c-maf","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_scheme":"Other"},{"subitem_subject":"ischemic-reperfusion renal injury","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学医学部第四内科学"},{"subitem_text_value":"東京女子医科大学医学部第四内科学"},{"subitem_text_value":"東京女子医科大学医学部第四内科学"},{"subitem_text_value":"東京女子医科大学医学部第四内科学"},{"subitem_text_value":"東京女子医科大学医学部第四内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006014805.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006014805.pdf","url":"https://twinkle.repo.nii.ac.jp/record/20426/files/KJ00006014805.pdf"},"version_id":"8e2c55c2-15ed-4043-98fa-ec6b3c9c06a1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"腎臓における酸化ストレス下のc-maf発現調節","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腎臓における酸化ストレス下のc-maf発現調節"}]},"item_type_id":"10001","owner":"3","path":["2030"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"20426","relation_version_is_last":true,"title":["腎臓における酸化ストレス下のc-maf発現調節"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T21:03:22.397162+00:00"}