@article{oai:twinkle.repo.nii.ac.jp:00020426,
 author = {大石, 哲也 and 芳田, 工 and 杉浦, 秀和 and 土谷, 健 and 新田, 孝作},
 issue = {1},
 journal = {東京女子医科大学雑誌},
 month = {Jan},
 note = {Maf is a family of oncogenes that encode a transcription factors containing a typical bZip structure -a motif for protein dimerization and DNA binding- and have been speculated to possess various potentials in mediating development, cellular differentiation and biological activities in several organs. Previously, we reported that c-maf modulates the antioxidative pathway via plasma glutathione peroxidase-3 in the proximal tubules of the mouse kidney. Therefore, we suggested that c-maf might play an important role in the presence of oxidative stress in the kidney. Here, we investigated c-maf expression in a rat model for renal ischemia reperfusion injury and cultured cells derived from human kidney proximal tubular cells (HK-2) treated with several oxidative compounds. The in vivo and in vitro experiments demonstrated that the expression of c-maf mRNA was relatively low during the early stage of oxidative stress but increased at a later stage. An immunohistochemical study showed a reduction in c-maf protein over a similar time course. Tunel staining in HK-2 cells that were overexpressing c-maf showed a tendency toward a protective effect against H_2O_2, and the expression of the c-maf gene was related to a decrease in p21 and p53. These data indicate that c-maf depletion may trigger apoptotic cell death under stressful conditions, suggesting that the c-maf gene may be related to anti-stress related genes.},
 pages = {10--17},
 title = {腎臓における酸化ストレス下のc-maf発現調節},
 volume = {78},
 year = {2008}
}