{"created":"2023-06-20T17:00:41.765920+00:00","id":20191,"links":{},"metadata":{"_buckets":{"deposit":"aa2fe67d-886c-454c-8cc2-271886aa5f21"},"_deposit":{"created_by":3,"id":"20191","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20191"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00020191","sets":["140:1307:1308:2014:2022"]},"author_link":["297600","297604","297601","297598","297605","297599","297603","297602"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"小児特発性血小板減少紫斑病におけるHelicobacter pylori感染の関与と除菌療法の有効性についての検討(東京女子医科大学東医療センター小児科開局40周年記念論文集)"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-05-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Extra","bibliographicPageEnd":"E45","bibliographicPageStart":"E40","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATO, Fumiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ARAI, Asako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WADA, Emiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGIHARA, Sigetaka"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_34":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"東京女子医科大学東医療センター小児科開局40周年記念論文集","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"特発性血小板減少性紫斑病(ITP)の成人例では,約70%の症例でHelicobacter pylori(H.pylori)感染を認め除菌成功例の半数以上で血小板が増加することから,ITPにおける除菌療法の有用性が確立されてきた.しかし,小児ITPでは,発症後6ヵ月以内に治癒する急性型の症例が多いこと,またH.pylori感染の検査感度が低いため成人と比較し診断が困難であることなどからH.pyloriの関与は明らかではない.今回われわれは,2000年7月～2006年6月までの6年間に当科でITPと診断された25例,男児15例,女児10例,発症年齢中央値2.8歳(生後3ヵ月～14歳)を対象にITPにおけるH.pyloriの関与について検討を行った.急性型が14例(56%),慢性型が11例(44%),慢性型は急性型と比較し女児に多く発症年齢が年長である傾向を示した.慢性型ITPに便中H.pylori抗原検査,尿素呼気テスト,または血清抗HPIgG抗体検査を施行した.11例中3例(27%,男児1例,女児2例)においてH.pyloriが陽性となり,H.pylori陽性例の3例に対してamoxicillin, clarithromycin, protonpump-inhibitorの3剤を14日間使用する除菌療法を行った.全例で除菌は成功し,1例(慢性ITPの9%,ITP症例中4%)において血小板が増加し完全寛解となった.2例では除菌療法の前後での血小板の変動は認められなかった.除菌療法の副作用は特に認められなかった.今回の検討から,小児ITPにおいてもH.pyloriが関与する症例があることから,一般的な治療に不応な慢性型小児ITP症例では除菌療法も考慮すべき治療法の一つであると思われた.","subitem_description_type":"Abstract"},{"subitem_description":"Eradication of Helicobacter pylori (H. pylori) has been established as the first line treatment for H. pylori-positive chronic idiopathic thrombocytopenic purpura (ITP) in adults according to the results of a nationwide retrospective study in Japan, but it is unclear whether H. pylori infection is a precipitating cause of ITP in children. We investigated the prevalence of H. pylori infection in 25 children (15 boys and 10 girls), median age 2.8 years, who had been diagnosed with ITP during the six years from July 2000 to June 2006. The 11 patients with chronic ITP (44%) were significantly older than the 14 patients with acute ITP (56%), and female gender was significantly associated with higher prevalence of chronic ITP. Testing for H. pylori stool antigen, the ^<13>C urea breath test, and/or testing for the presence of serum anti-H. pylori IgG antibody was performed in the 11 children with chronic ITP. H. pylori infection was diagnosed in three of them (1 boy and 2 girls), and eradication therapy was successful in all three of them. The platelet count in one of the cases increased after the eradication therapy. In conclusion, H. pylori infection was present in 27% of the children with chronic ITP, and eradication therapy may be warranted for children with H. pylori-positive chronic ITP that is refractory to conventional therapy.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"297602","nameIdentifierScheme":"WEKO"}],"names":[{"name":"加藤, 文代"}]},{"nameIdentifiers":[{"nameIdentifier":"297603","nameIdentifierScheme":"WEKO"}],"names":[{"name":"新井, 麻子"}]},{"nameIdentifiers":[{"nameIdentifier":"297604","nameIdentifierScheme":"WEKO"}],"names":[{"name":"和田, 恵美子"}]},{"nameIdentifiers":[{"nameIdentifier":"297605","nameIdentifierScheme":"WEKO"}],"names":[{"name":"杉原, 茂孝"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"idiopathic thrombocytopenic purpura (ITP)","subitem_subject_scheme":"Other"},{"subitem_subject":"Helicobacter pylori (H. pylori)","subitem_subject_scheme":"Other"},{"subitem_subject":"eradication","subitem_subject_scheme":"Other"},{"subitem_subject":"child","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University Medical Center East"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University Medical Center East"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University Medical Center East"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University Medical Center East"},{"subitem_text_value":"東京女子医科大学東医療センター小児科"},{"subitem_text_value":"東京女子医科大学東医療センター小児科"},{"subitem_text_value":"東京女子医科大学東医療センター小児科"},{"subitem_text_value":"東京女子医科大学東医療センター小児科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006017910.pdf","filesize":[{"value":"515.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006017910.pdf","url":"https://twinkle.repo.nii.ac.jp/record/20191/files/KJ00006017910.pdf"},"version_id":"21a49560-f737-4f8b-879c-9f4a3610893f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Helicobacter pylori Infection in Children with Idiopathic Thrombocytopenic Purpura and the Efficacy of Eradication Therapy(Papers for cerebrating the Forty Aniversary of the Department of Pediatrics, Tokyo Women's Medical University Center East)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Helicobacter pylori Infection in Children with Idiopathic Thrombocytopenic Purpura and the Efficacy of Eradication Therapy(Papers for cerebrating the Forty Aniversary of the Department of Pediatrics, Tokyo Women's Medical University Center East)"}]},"item_type_id":"10001","owner":"3","path":["2022"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"20191","relation_version_is_last":true,"title":["Helicobacter pylori Infection in Children with Idiopathic Thrombocytopenic Purpura and the Efficacy of Eradication Therapy(Papers for cerebrating the Forty Aniversary of the Department of Pediatrics, Tokyo Women's Medical University Center East)"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:57:50.895040+00:00"}