@article{oai:twinkle.repo.nii.ac.jp:00019769,
 author = {NAKAZAWA, Tomoko and YAMAURA, Hisashi and SHIMIZU, Satoru and NISHIKAWA, Megumi and EZAKI, Taichi and AIKAWA, Eizo},
 issue = {2},
 journal = {東京女子医科大学雑誌},
 month = {Feb},
 note = {老化促進マウス(SAMP)の加齢変化は,対照群となるSAMRよりも早く現れることが知られている.著者らは,これまでラット脳血管周囲マクロファージが加齢とともに,その数や細胞形態において変化することを報告してきた.そこで,この研究では. SAMP8と対照群のSAMR1を用いて,脳の血管周囲マクロファージの電子密度の高い顆粒(dense granule)と泡沫状顆粒(foamy granule)について,それぞれの形態と数の変化について年齢を追って観察した.類粒は加齢とともにelectron-denseからfoamyに変わりdense granuleは減少する.逆にfoamy granuleは4～6ヵ月頃から急速に増え,さらに加齢とともに増える.以上の結果より,マクロファージ内のfoamy granuleへの変化は,老化の初期段階の兆候の一つであり,この兆候は,SAMP8においてSAMR1より,促進されていた., Both morphological and quantitative changes in electron-dense granules and foamy granules of the brain perivascular macrophages were investigated using senescence accelerated prone mice (SAMP) at different ages. Perivascular macrophages scavenge high molecular weight substances, such as low-density lipoprotein, incorporating them into granules in the cytoplasm. In this study, SAMPS and control SAMR1, 2-19 months of age, were examined to characterize these granules in perivascular macrophages of the brain. The number of granules were counted in animals of each age studied and were observed to change with aging from dense to foamy granules in perivascular macrophages. Dense granules gradually diminished starting after 2 months until 10 months postnatally, but foamy granules increased after 4-6 postnatal months. Foamy granules showed a quicker increase in SAMPS than in SAMR1 around 6 months of age. These results suggested that the morphological changes in granules of perivascular macrophages are characteristics of aging and more accelerated in senescence accelerated SAMPS, than in control SAMR1.},
 pages = {82--91},
 title = {Acceleration of Age-related Changes in the Granules of Perivascular Macrophages from the Brain of Senescence Accelerated Mice (SAM)},
 volume = {76},
 year = {2006}
}