{"created":"2023-06-20T17:00:12.222625+00:00","id":19527,"links":{},"metadata":{"_buckets":{"deposit":"26e0337f-fa76-4b9b-90ad-cb80c6c127e3"},"_deposit":{"created_by":3,"id":"19527","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19527"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00019527","sets":["140:1307:1308:1995:1998"]},"author_link":["298351","298356","298353","298349","298350","298352","298355","298357","298358","298354"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"閉塞性黄疸解除後における肝切除後の肝再生 : 脂質代謝からみた実験的研究"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"123","bibliographicPageStart":"115","bibliographicVolumeNumber":"75","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TAKAHASHI, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIOZAWA, Shun-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUCHIYA, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KIM, Dal Ho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OGAWA, Kenji"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"閉塞性黄疸を有する肝・胆道疾患に対して肝切除を行う場合,適切な黄疸解除処置を行った上で肝切除を施行しても術後に肝不全となる症例を経験する.この原因の一つに,黄疸解除後も肝再生が遷延することが挙げられる.一般に,肝再生時には細胞膜の合成に必要なコレステロール,リン脂質の合成が亢進する.しかし,黄疸解除後の肝臓における肝再生について,こうした脂質代謝の面から検討した報告はない.そこで本研究では,とくに臨床上問題となる閉塞性黄疸解除後の肝再生に脂質代謝がどのように関わるか実験的に検討した.Wistar系雄性ラット(10週齢)に閉塞性黄疸を作製し,黄疸解除後1週目に70%肝切除を行った.対照として,正常ラットに同じ方法で70%肝切除を加えた.肝切除前および切除後1,3,5,7日目にラットを犠牲死させ,下大静脈より採血し,肝機能や脂質代謝の推移を検索した.また残肝を全摘出し,肝再生能と肝再生に重要な肝組織におけるコレステロール取り込み能および合成能を測定した.結果として(1)閉塞性黄疸では,黄疸解除によりみかけの肝機能は回復しても脂質代謝の障害は遷延する,(2)閉塞性黄疸解除後の肝切除では,正常肝の肝切除に比べて肝再生が遷延する,(3)肝再生の遷延を脂質代謝の面からみると,こうした肝臓では,肝再生のために必要なコレステロールは急速に生合成されているが,このコレステロールが細胞膜合成に利用されていない,などが明らかとなった.利用されない原因は不明であるが,このことを中心とした肝臓における脂質代謝の障害が肝再生を遷延させる一因と考えられる.今後は,この利用されない原因の究明が重要と考えている.","subitem_description_type":"Abstract"},{"subitem_description":"The present experimental study was carried out to determine how lipid metabolism was involved in the clinically important liver regeneration after hepatectomy for obstructive jaundice followed by biliary drainage. Experimental obstructive jaundice was prepared in rats, 1 week after which biliary drainage was performed. After 1 additional week, an approximate 70%-partial hepatectomy was performed in some rats. Similarly, the control rats received a 70%-partial hepatectomy. A profile of the time-sequential changes in lipid metabolism and liver regeneration in the residual liver was investigated and compared between both animal groups that underwent hepatectomy. Liver regeneration after hepatectomy in obstructive jaundice after biliary drainage was delayed compared with that of a resected normal liver. In the injured liver, however, lipid metabolism greatly contributed to rapid synthesis of cholesterol necessary for liver regeneration. The synthesized cholesterol was not utilized for the formation of cell membrane in the liver, which suggests potential damage in these processes. Future studies would warrant clarification of why the cholesterol synthesized in the liver was not used for cell membrane synthesis.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"298354","nameIdentifierScheme":"WEKO"}],"names":[{"name":"高橋, 弘"}]},{"nameIdentifiers":[{"nameIdentifier":"298355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"塩澤, 俊一"}]},{"nameIdentifiers":[{"nameIdentifier":"298356","nameIdentifierScheme":"WEKO"}],"names":[{"name":"土屋, 玲"}]},{"nameIdentifiers":[{"nameIdentifier":"298357","nameIdentifierScheme":"WEKO"}],"names":[{"name":"金, 達浩"}]},{"nameIdentifiers":[{"nameIdentifier":"298358","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小川, 健治"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"liver regeneration","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatectomy","subitem_subject_scheme":"Other"},{"subitem_subject":"obstructive jaundice","subitem_subject_scheme":"Other"},{"subitem_subject":"biliary drainage","subitem_subject_scheme":"Other"},{"subitem_subject":"lipid metabolism","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Surgery, Tokyo Women's Medical University Daini Hospital"},{"subitem_text_value":"Department of Surgery, Tokyo Women's Medical University Daini Hospital"},{"subitem_text_value":"Department of Surgery, Tokyo Women's Medical University Daini Hospital"},{"subitem_text_value":"Department of Surgery, Tokyo Women's Medical University Daini Hospital"},{"subitem_text_value":"Department of Surgery, Tokyo Women's Medical University Daini Hospital"},{"subitem_text_value":"東京女子医科大学附属第二病院外科"},{"subitem_text_value":"東京女子医科大学附属第二病院外科"},{"subitem_text_value":"東京女子医科大学附属第二病院外科"},{"subitem_text_value":"東京女子医科大学附属第二病院外科"},{"subitem_text_value":"東京女子医科大学附属第二病院外科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006018445.pdf","filesize":[{"value":"756.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006018445.pdf","url":"https://twinkle.repo.nii.ac.jp/record/19527/files/KJ00006018445.pdf"},"version_id":"8ca2ddd0-2ef5-4c80-8d3b-ef3e2b556891"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Experimental Studies on Liver Regeneration after Partial Hepatectomy in Rats with Obstructive Jaundice after Biliary Drainage : with Special Reference to Lipid Metabolism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Experimental Studies on Liver Regeneration after Partial Hepatectomy in Rats with Obstructive Jaundice after Biliary Drainage : with Special Reference to Lipid Metabolism"}]},"item_type_id":"10001","owner":"3","path":["1998"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"19527","relation_version_is_last":true,"title":["Experimental Studies on Liver Regeneration after Partial Hepatectomy in Rats with Obstructive Jaundice after Biliary Drainage : with Special Reference to Lipid Metabolism"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T20:56:32.677464+00:00"}