{"created":"2023-06-20T17:00:10.712064+00:00","id":19494,"links":{},"metadata":{"_buckets":{"deposit":"1d652c4e-2526-444b-b773-45df04f93932"},"_deposit":{"created_by":3,"id":"19494","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19494"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00019494","sets":["140:1307:1308:1995:1997"]},"author_link":["294245","294246","294241","294249","294256","294250","294242","294252","294244","294247","294253","294248","294254","294243","294255","294251"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"自閉症におけるメチルコバラミン療法の予備的検討"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"69","bibliographicPageStart":"64","bibliographicVolumeNumber":"75","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKANO, Kazutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NODA, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TACHIKAWA, Emiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"URANO, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAZAWA, Miyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAYAMA, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAKI, Kaori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OSAWA, Makiko"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は13例の自閉症患者でビタミンB_<12>(メチルコバラミン:Me-B_<12>)の治療効果をオープン試験で試みた.Me-B_<12>の治療開始時期は2歳3ヵ月から18歳で,Me-B_<12>を25～30μg/kg/day,6～25ヵ月間投与した.IQ/DQによる評価では,治療前は45±5.3(平均±標準誤差)であったが,治療後は52±6.0と有意な上昇が認められた(p=0.0199).CARS検査(小児自閉症評定尺度)では,治療前は35.9±1.6であったが,治療後は33.0±1.7(p=0.0008)と改善した.自然経過による改善とMe-B_<12>効果を鑑別するため,患者を年齢,知能でそれぞれ2群に分類し検討したところ,思春期群と低IQ群のCARSスコアーが,幼児・早期学童期群,高IQ群と同様に改善した.自閉症児において思春期は一般に症状改善に乏しく,症状の自然改善は高機能自閉症児に見られることから,この結果は, Me-B_<12>効果は自然経過とは異なると考えられた.検討はまだ予備的段階であるが,自閉症においてMe-B_<12>は治療薬として試みる価値があると考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"We conducted an open trial on the effect of methylcobalamin (Me-B_<12>) in 13 patients with autism. The patients' ages at the start of treatment ranged from 2 years and 3 months to 18 years. Me-B_<12> was administered at a dosage of 25-30 g/kg/day for 6-25 months. The intelligence and developmental quotient (IQ/DQ) after Me-B_<12>treatment was 52±6.0 (mean ± SE), which was significantly higher than before treatment (45±5.3) (p<0.05). The childhood autism rating scale (CARS) score improved significantly, from 35.9±1.6 before to 33.0±1.7 after treatment (p<0.001). To distinguish the effects of Me-B_<12> from natural developmental factors, the patients were divided into two subgroups, both according to age and according to intelligence. The CARS scores of the teenage and the low-IQ groups improved as much as those of the pre-early school age and the high-IQ groups. As adolescent autism patients usually show a decline in their condition, while some high function autism patients exhibit positive development, the improvement of CARS scores with Me-B_<12> treatment in the teenage and the low-IQ groups suggests that the Me-B_<12> effect is distinct from developmental factors. Although these data are very preliminary, Me-B_<12> is potentially beneficial in autism as an additional or alternative treatment.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"294249","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中野, 和俊"}]},{"nameIdentifiers":[{"nameIdentifier":"294250","nameIdentifierScheme":"WEKO"}],"names":[{"name":"野田, 尚子"}]},{"nameIdentifiers":[{"nameIdentifier":"294251","nameIdentifierScheme":"WEKO"}],"names":[{"name":"立川, 恵美子"}]},{"nameIdentifiers":[{"nameIdentifier":"294252","nameIdentifierScheme":"WEKO"}],"names":[{"name":"浦野, 真理"}]},{"nameIdentifiers":[{"nameIdentifier":"294253","nameIdentifierScheme":"WEKO"}],"names":[{"name":"高澤, みゆき"}]},{"nameIdentifiers":[{"nameIdentifier":"294254","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中山, 智博"}]},{"nameIdentifiers":[{"nameIdentifier":"294255","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐々木, 香織"}]},{"nameIdentifiers":[{"nameIdentifier":"294256","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大澤, 真木子"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"autism","subitem_subject_scheme":"Other"},{"subitem_subject":"IQ","subitem_subject_scheme":"Other"},{"subitem_subject":"methylcobalamin","subitem_subject_scheme":"Other"},{"subitem_subject":"childhood autism rating scale (CARS)","subitem_subject_scheme":"Other"},{"subitem_subject":"methylation cycle","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Tokyo Women's Medical University School of Medicine"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006018424.pdf","filesize":[{"value":"561.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006018424.pdf","url":"https://twinkle.repo.nii.ac.jp/record/19494/files/KJ00006018424.pdf"},"version_id":"9815e9c3-2d2f-4c56-9507-de8ff4708b08"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Preliminary Study of Methylcobalamin Therapy in Autism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Preliminary Study of Methylcobalamin Therapy in Autism"}]},"item_type_id":"10001","owner":"3","path":["1997"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"19494","relation_version_is_last":true,"title":["A Preliminary Study of Methylcobalamin Therapy in Autism"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T21:03:06.546675+00:00"}