{"created":"2023-06-20T16:59:59.529485+00:00","id":19247,"links":{},"metadata":{"_buckets":{"deposit":"357198f4-bd95-43c1-9999-25b73540301e"},"_deposit":{"created_by":3,"id":"19247","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19247"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00019247","sets":["140:1307:1308:1984:1989"]},"author_link":["300548","300550","300551","300549","300546","300547"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pathophysiology and Treatment of Airway Hypersecretion"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"255","bibliographicPageStart":"248","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"近藤, 光子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"玉置, 淳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永井, 厚志"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Excessive sputum due to airway hypersecretion is one of the common symptoms in respiratory diseases such as asthma and bronchiectasis. Airway secretion is mainly composed of mucin from airway goblet cells and submucosal glands and water through ion transport in airway epithelial cells. Although airway secretion plays an important role in defense mechanism, the increase in intraluminal mucus may lead to the impairment of mucociliary clearance and airway obstruction. Airway secretion is stimulated by autonomic nervous system and a variety of chemical mediators, but these mechanisms are different under individual conditions. It is thus important to select mucoregulating drugs after understanding the pathophysiology of hypersecretion. Recent evidence suggests that goblet cell hyperplasia and mucin overproduction are associated with Th2 cytokines such as IL-13, EGF-receptor, and Ca activated Cl channels. The new therapeutic approach based on the evidence could be developed in the future.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"300549","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KONDO, Mitsuko"}]},{"nameIdentifiers":[{"nameIdentifier":"300550","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAMAOKI, Jun"}]},{"nameIdentifiers":[{"nameIdentifier":"300551","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAGAI, Atsushi"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"sputum","subitem_subject_scheme":"Other"},{"subitem_subject":"mucociliary clearance","subitem_subject_scheme":"Other"},{"subitem_subject":"goblet cell hyperplasia","subitem_subject_scheme":"Other"},{"subitem_subject":"mucin","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-13","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学医学部第一内科学"},{"subitem_text_value":"東京女子医科大学医学部第一内科学"},{"subitem_text_value":"東京女子医科大学医学部第一内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006018863.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006018863.pdf","url":"https://twinkle.repo.nii.ac.jp/record/19247/files/KJ00006018863.pdf"},"version_id":"af82b75d-78c8-4ac4-b8c3-bb6aee9ac24e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"気道分泌亢進の病態と治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"気道分泌亢進の病態と治療"}]},"item_type_id":"10001","owner":"3","path":["1989"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"19247","relation_version_is_last":true,"title":["気道分泌亢進の病態と治療"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T20:52:40.645246+00:00"}