{"created":"2023-06-20T16:59:44.587396+00:00","id":18908,"links":{},"metadata":{"_buckets":{"deposit":"1cdb4597-6067-4944-b7d6-780c78c6f36e"},"_deposit":{"created_by":3,"id":"18908","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18908"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00018908","sets":["140:1307:1308:1974:1977"]},"author_link":["294258","294257"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Autoimmune Hepatitis"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-05-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"132","bibliographicPageStart":"126","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 直諒"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated many cases of autoimmune hepatitis depending on an acute phase or a chronic phase and proposed here the crucial points on diagnostic definition and treatment. In an acute phase, many cases lack positive auto-antibodies and hyper-γ-globulinemia which are typical feature in chronic phase of autoimmune hepatitis. Thus, the current diagnostic definition of autoimmune hepatitis is not sufficient to uncover acute phase of disease. Histologically, multi-lobular and diffuse hepatic degeneration and necrosis are initially observed and irreversible degeneration gave an atrophic change on some area, leading to wide and flat depression on a surface of liver which process brings out potato liver macroscopically. To suppress the progression of acute phase of autoimmune hepatitis we need the initial treatment of predonisolone within 1.5 month and basically with combination with Imuran. After treatment of acute phase, we control the disease with a maintaining dose of 7.5～2.5 mg/day of predonisolone. In a chronic phase autoimmune hepatitis repeatedly relapse and progress to liver cirrhosis consistent with positive auto-antibodies and prominent hyper-γ-globulinemia. The typical case of autoimmune hepatitis diagnosed with the current definition may show an exacerbated phase or a relapse phase of chronic autoimmune hepatitis.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"294258","nameIdentifierScheme":"WEKO"}],"names":[{"name":"HAYASHI, Naoaki"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"autoimmune hepatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical course","subitem_subject_scheme":"Other"},{"subitem_subject":"acute hepatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical criteria","subitem_subject_scheme":"Other"},{"subitem_subject":"prednisolone","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学医学部消化器内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006019185.pdf","filesize":[{"value":"979.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006019185.pdf","url":"https://twinkle.repo.nii.ac.jp/record/18908/files/KJ00006019185.pdf"},"version_id":"da73f5b7-fc81-41ef-bbc1-0283016822e7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"自己免疫性肝炎について(特別講演,<特集>第68回東京女子医科大学学会総会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自己免疫性肝炎について(特別講演,<特集>第68回東京女子医科大学学会総会)"}]},"item_type_id":"10001","owner":"3","path":["1977"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"18908","relation_version_is_last":true,"title":["自己免疫性肝炎について(特別講演,<特集>第68回東京女子医科大学学会総会)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T21:03:05.393498+00:00"}