{"created":"2023-06-20T16:59:43.417121+00:00","id":18882,"links":{},"metadata":{"_buckets":{"deposit":"3e7e51e5-fb2a-49f6-ab32-c40b60a25142"},"_deposit":{"created_by":3,"id":"18882","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18882"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00018882","sets":["140:1307:1308:1974:1976"]},"author_link":["300615","300610","300607","300613","300612","300608","300611","300614","300616","300609"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"根治切除不能再発胃malignant GISTに対しSTI571が著効した1例"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"109","bibliographicPageStart":"105","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KITAMURA, Yoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OGUMA, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAGAWA, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKASAKI, Ken"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"症例は40歳男性.胃malignant GIST原発巣切除術後再発をきたし,約2年6ヵ月の間に5回の再発巣切除を行った.しかし,再度再発し,骨盤から胸腔内まで多発転移巣を認め,腹部大動脈周囲を取り巻くように再発巣があることから根治切除不能と診断した.原発巣および切除転移巣の免疫染色においてc-kit陽性であったことからイマニチブの投与を開始した.6週間後の腹部CT検査において大動脈周囲転移巣の消失,肝転移巣,腹腔内転移巣の縮小,壊死化を認め,4ヵ月後の肝転移巣超音波下穿刺組織診において腫瘍細胞を認めなかった.これまでGISTに対する有効な化学療法はなかったがイマニチブの投与は再発GISTの治療において第一選択となる可能性があると考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"Gastrointestinal stromal tumors (GIST) have been considered chemoresistant, but recent reports have demonstrated the efficacy of STI571 (imatinib), a tyrosine kinase inhibitor, for c-kit positive GIST. We describe our experience with a patient with radically unresectable recurrent gastric GIST which significantly responded to STI571. A 40-year-old man underwent cardiectomy due to cardial submucosal tumor, which was diagnosed as malignant GIST by histopathology. However, this tumor relapsed in the abdominal cavity 15 months after the first surgery and the recurrent tumor was resected again. The patient experienced five relapses in the abdominal cavity and liver in about 30 months, and every time surgical resection was performed. Finally this patient was admitted for the seventh time due to tumors developing in the mesenterium and remnant liver in October 2001. Encouraged by recent successful clinical reports of STI571 against GIST, STI571 twice daily at 400 mg/day was administered orally, and CT scan at week 6 showed disappearance of the tumor surrounding the aorta, regression of the metastatic liver tumor and the tumor beside the spleen. Abdominal CT scan after 4 months showed further regression of the tumors. Aspiration cytology of metastatic liver tumor did not show any distinctive tumor cells. STI571 is thought to be a possible standard treatment for patients with GIST.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"300612","nameIdentifierScheme":"WEKO"}],"names":[{"name":"喜多村, 陽一"}]},{"nameIdentifiers":[{"nameIdentifier":"300613","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小熊, 英俊"}]},{"nameIdentifiers":[{"nameIdentifier":"300614","nameIdentifierScheme":"WEKO"}],"names":[{"name":"笹川, 剛"}]},{"nameIdentifiers":[{"nameIdentifier":"300615","nameIdentifierScheme":"WEKO"}],"names":[{"name":"林, 和彦"}]},{"nameIdentifiers":[{"nameIdentifier":"300616","nameIdentifierScheme":"WEKO"}],"names":[{"name":"高崎, 健"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_47":{"attribute_name":"著者キーワード","attribute_value_mlt":[{"subitem_subject":"stomach","subitem_subject_scheme":"Other"},{"subitem_subject":"GIST","subitem_subject_scheme":"Other"},{"subitem_subject":"STI571","subitem_subject_scheme":"Other"},{"subitem_subject":"imatinib","subitem_subject_scheme":"Other"},{"subitem_subject":"chemotherapy","subitem_subject_scheme":"Other"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University"},{"subitem_text_value":"Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University"},{"subitem_text_value":"Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University"},{"subitem_text_value":"Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University"},{"subitem_text_value":"Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University"},{"subitem_text_value":"東京女子医科大学消化器病センター外科"},{"subitem_text_value":"東京女子医科大学消化器病センター外科"},{"subitem_text_value":"東京女子医科大学消化器病センター外科"},{"subitem_text_value":"東京女子医科大学消化器病センター外科"},{"subitem_text_value":"東京女子医科大学消化器病センター外科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-22"}],"displaytype":"detail","filename":"KJ00006019168.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006019168.pdf","url":"https://twinkle.repo.nii.ac.jp/record/18882/files/KJ00006019168.pdf"},"version_id":"6fd68284-c3b4-4c26-b8ee-130f838068e7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Patient with Recurrent Malignant Gastrointestinal Stromal Tumors Who Completely Responded to STI571","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Patient with Recurrent Malignant Gastrointestinal Stromal Tumors Who Completely Responded to STI571"}]},"item_type_id":"10001","owner":"3","path":["1976"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"18882","relation_version_is_last":true,"title":["A Patient with Recurrent Malignant Gastrointestinal Stromal Tumors Who Completely Responded to STI571"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T20:52:33.771516+00:00"}