{"created":"2023-06-20T16:59:39.874052+00:00","id":18826,"links":{},"metadata":{"_buckets":{"deposit":"c064c52b-a729-4968-b757-67dc4af6362c"},"_deposit":{"created_by":3,"id":"18826","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18826"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00018826","sets":["140:1307:1308:1965:1973"]},"author_link":["266862","266863","266861","266868","266864","266860","266866","266865","266869","266867"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"HBVとHCVの重複感染者とHBV単独感染者間のHBeAgセロコンバージョンの機構の比較"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"520","bibliographicPageStart":"513","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NARITOMI, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HASEGAWA, Kiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TORII, Nobuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"JOH, Riho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Naoaki"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HBVとHCVの重感染者におけるセロコンバージョン(SC)の機序を明らかにすることを目的に,HBV単独感染者とHBVとHCVの重複感染者において,E-II/CP領域とpreC/C領域のsequenceを比較した.対象はHBsAg陽性,HBeAg陰性,HBeAb陽性,HCV-RNA陽性の慢性肝炎患者7例とHBsAg陽性,HBeAg陰性,HBeAb陽性,HCV-RNA陰性の慢性肝炎患者10例である.保存血清よりDNAを抽出しdirect sequence法でE-II/CP領域とpreC/C領域の遺伝子解析をした.単独感染者の7例はジェノタイプCで,2例はジェノタイプBであった.重複感染者の4例はジェノタイプCで,2例はジェノタイプBであった.1896番の塩基のグアニンからアデニンへの変異は,重複感染者の7例中3例,単独感染者の10例中9例で認め,2群間で有意差があった.また,コア領域の13番と35番のアミノ酸変異は単独感染者に有意に認めた.コアプロモーター領域の塩基変異は2群間で差はなかった.プレコア領域の塩基変異には有意差を認めた.このことは,2群間におけるHBeAgのSC後のHBVの存在様式が異なることを示唆した.","subitem_description_type":"Abstract"},{"subitem_description":"Hepatitis B virus (HBV) occasionally co-infects with hepatitis C virus (HCV). Because replication of HBV is suppressed by HCV core protein in double infection, HBV is usually inactive in such case. In light of these facts, we examined HBV from patients who were negative for hepatitis B virus e antigen (HBe Ag) and positive for anti-HBe for differences in sequence of the core promoter and precore region between patients with and without HCV co-infection. The subjects were 17 HBeAg-negative/anti-HBe-positive chronic hepatitis B patients divided into 2 groups: 10 without HCV, and 7 with HCV. DNA from the core promoter to the core gene was directly sequenced and compared between these 2 groups. There was a significant difference in the frequency of a change from guanine to adenine at nucleotide 1896 between patients with double infection (3 out of 7) and patients infected with HBV alone (9 out of 10) (p<0.05). Seven of the patients with HBV alone had genotype C, and 2 had genotype B. Four of the patients with double infection had genoype C, and 2 had genoype B. In the core region, mutations at amino acids 13 and 35 were significantly more frequent in patients with HBV alone. There was no difference in the sequence of the core promoter between the 2 groups. There were significant differences in the sequence of the precore region between patients infected with HBV alone and patients with a double infection of HBV and HCV. This suggests that the mechanisms by which HBV persists after seroconversion of HbeAg differs between patients with double infection and patients with HBV alone.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"266865","nameIdentifierScheme":"WEKO"}],"names":[{"name":"成冨, 琢磨"}]},{"nameIdentifiers":[{"nameIdentifier":"266866","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長谷川, 潔"}]},{"nameIdentifiers":[{"nameIdentifier":"266867","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鳥居, 信之"}]},{"nameIdentifiers":[{"nameIdentifier":"266868","nameIdentifierScheme":"WEKO"}],"names":[{"name":"城, 里穂"}]},{"nameIdentifiers":[{"nameIdentifier":"266869","nameIdentifierScheme":"WEKO"}],"names":[{"name":"林, 直諒"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Medicine Institute of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Medicine Institute of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Medicine Institute of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Medicine Institute of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"Department of Medicine Institute of Gastroenterology, Tokyo Women's Medical University, School of Medicine"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"},{"subitem_text_value":"東京女子医科大学医学部消化器内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006019681.pdf","filesize":[{"value":"598.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006019681.pdf","url":"https://twinkle.repo.nii.ac.jp/record/18826/files/KJ00006019681.pdf"},"version_id":"c4cf6d1e-f07f-428d-8f80-00f4601777a4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of the Mechanisms of HBeAg Seroconversion Among Patients with HBV and HCV, and with HBV Alone","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of the Mechanisms of HBeAg Seroconversion Among Patients with HBV and HCV, and with HBV Alone"}]},"item_type_id":"10001","owner":"3","path":["1973"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"18826","relation_version_is_last":true,"title":["Comparison of the Mechanisms of HBeAg Seroconversion Among Patients with HBV and HCV, and with HBV Alone"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T22:21:39.217399+00:00"}