{"created":"2023-06-20T16:59:13.993962+00:00","id":18257,"links":{},"metadata":{"_buckets":{"deposit":"0694b680-135d-4db1-a17b-d1f034d31db9"},"_deposit":{"created_by":3,"id":"18257","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18257"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00018257","sets":["140:1307:1308:1944:1955"]},"author_link":["265613","265617","265621","265619","265615","265624","265626","265622","265618","265627","265616","265623","265612","265629","265628","265620","265614","265625"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Effect of Immunoadsorption Therapy in Acute Disseminated Encephalomyelitis(Special Issue in Hornor of the Retirement of Professor Toshiko Takemiya at the Department of Neurology, Tokyo Women's Medical University)"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"E2","bibliographicPageEnd":"E392","bibliographicPageStart":"E386","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 優子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 宏平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堤, 由紀子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大原, 久仁子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉澤, 浩志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹宮, 敏子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩田, 誠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山内, 照夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相川, 隆司"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_34":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"神経内科学教室竹宮敏子教授退任記念特別号","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Acute disseminated encephalomyelitis (ADEM) seems to be an immune-mediated demyelinating disorder of the central nervous system (CNS). Corticosteroid administration is a commonly used treatment for ADEM. Recently, several reports on the successful use of plasmapheresis (PP) in ADEM were presented. We described the efficacy of PP as the immunoadsorption therapy (IAT) for two patients with severe ADEM who did not respond to corticosteroids. One patient developed stupor, bilateral facial weakness, bulbar palsy and tetraplegia, and the other patient developed delirium, muscle weakness of the arms and legs, and external ophthalmoplegia from the administration of corticosteroid. After IAT, both patients recovered remarkably well. Laboratory studies revealed a elevation of the IgG index, an increase in suppressor-inducer T cells and activated T cells, and that anti-GQ1b antibody was positive in the peripheral blood. These abnormalities improved after IAT. The mechanism of efficacy of IAT is unknown, but IAT might correct the immune function by modulating cytokines and removing the toxic substances, which lead to the autoimmune response in the CNS. Our observations suggested that IAT may be a beneficial treatment for severe ADEM.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"265621","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SHIMIZU, Yuko"}]},{"nameIdentifiers":[{"nameIdentifier":"265622","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OTA, Kohei"}]},{"nameIdentifiers":[{"nameIdentifier":"265623","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TSUTSUMI, Yukiko"}]},{"nameIdentifiers":[{"nameIdentifier":"265624","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OHARA, Kuniko"}]},{"nameIdentifiers":[{"nameIdentifier":"265625","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YOSHIZAWA, Hiroshi"}]},{"nameIdentifiers":[{"nameIdentifier":"265626","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAKEMIYA, Toshiko"}]},{"nameIdentifiers":[{"nameIdentifier":"265627","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IWATA, Makoto"}]},{"nameIdentifiers":[{"nameIdentifier":"265628","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YAMAUCHI, Teruo"}]},{"nameIdentifiers":[{"nameIdentifier":"265629","nameIdentifierScheme":"WEKO"}],"names":[{"name":"AIKAWA, Takashi"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学脳神経センター神経内科"},{"subitem_text_value":"東京女子医科大学脳神経センター神経内科"},{"subitem_text_value":"東京女子医科大学脳神経センター神経内科"},{"subitem_text_value":"東京女子医科大学脳神経センター神経内科"},{"subitem_text_value":"東京女子医科大学脳神経センター神経内科"},{"subitem_text_value":"東京女子医科大学脳神経センター神経内科"},{"subitem_text_value":"東京女子医科大学脳神経センター神経内科"},{"subitem_text_value":"至誠会第二病院神経内科"},{"subitem_text_value":"至誠会第二病院神経内科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006020671.pdf","filesize":[{"value":"807.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006020671.pdf","url":"https://twinkle.repo.nii.ac.jp/record/18257/files/KJ00006020671.pdf"},"version_id":"a022d711-e678-4f07-a8d5-a37582c6df10"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"急性散在性脳脊髄炎における免疫吸着療法の有効性(神経内科学教室竹宮敏子教授退任記念特別号)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"急性散在性脳脊髄炎における免疫吸着療法の有効性(神経内科学教室竹宮敏子教授退任記念特別号)"}]},"item_type_id":"10001","owner":"3","path":["1955"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"18257","relation_version_is_last":true,"title":["急性散在性脳脊髄炎における免疫吸着療法の有効性(神経内科学教室竹宮敏子教授退任記念特別号)"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:54:41.020209+00:00"}