{"created":"2023-06-20T16:58:57.946938+00:00","id":17900,"links":{},"metadata":{"_buckets":{"deposit":"a63c8c7a-3d94-481c-8368-58c4c5bb7a74"},"_deposit":{"created_by":3,"id":"17900","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17900"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00017900","sets":["140:1307:1308:1944:1949"]},"author_link":["264430","264426","264431","264433","264429","264434","264427","264432","264428","264435"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Treatment of Three Children Who Developed Acute Lymphoblastic Leukemia with Carbamazepine(Papers for Cerebrating the Fifth Aniversary of the Directorship of Prof. M. Osawa at the Department of Pediatrics, Tokyo Women's Medical University)"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"E1","bibliographicPageEnd":"E126","bibliographicPageStart":"E122","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山岡, 光子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今井, 薫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"砂原, 眞理子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福山, 幸夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大澤, 真木子"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_34":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"小児科学教室大澤真木子教授開講5周年記念特集","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Three epileptic children who had been treated with antiepileptic drugs (AED) including carbamazepine (CBZ) were eventually found to be suffering from acute lymphoblastic leukemia (ALL). Case 1, a boy, had been healthy until age 8, when generalized tonic-clonic seizures first occurred. Seizures persisted despite treatment with phenobarbital sodium (PB), phenytoin (PHT) and valproate sodium (VPA). At the age of 9, complex partial seizures (CPS) developed in this boy. CBZ was therefore added to the treatment regimen, and the previous prescription was stopped. Five months later, it was found that the boy was suffering from ALL. Case 2, also a boy, was born with complicating intraventricular hemorrhage in the neonatal period. An epileptiform EEG abnormality was noticed at age 2, when VPA administration was started. Despite this, an episode of CPS occurred at the age of 4, which prompted us to switch the treatment from VPA to CBZ. His later course was uneventful until the age of 8, when hematological problems became evident, and a diagnosis of ALL was made. Case 3, a boy, was initially treated with CBZ because of autism and EEG abnormality at 12 years of age. In addition to CBZ, haloperidol and promethazine hydrochloride were given at the age of 13 years. ALL developed at the age of 14 years 2 months. In summary, ALL was noticed in three epileptic boys on AED therapy, all of whom were receiving CBZ. No causal relationship between AED (especially CBZ) and ALL has been established. While these three cases may represent mere coincidence, they may also suggest that we should keep ALL in mind when treating children with AED therapy.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"264431","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YAMAOKA, Mitsuko"}]},{"nameIdentifiers":[{"nameIdentifier":"264432","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IMAI, Kaoru"}]},{"nameIdentifiers":[{"nameIdentifier":"264433","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SUNAHARA, Mariko"}]},{"nameIdentifiers":[{"nameIdentifier":"264434","nameIdentifierScheme":"WEKO"}],"names":[{"name":"FUKUYAMA, Yukio"}]},{"nameIdentifiers":[{"nameIdentifier":"264435","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OSAWA, Makiko"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"},{"subitem_text_value":"東京女子医科大学医学部小児科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006020634.pdf","filesize":[{"value":"448.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006020634.pdf","url":"https://twinkle.repo.nii.ac.jp/record/17900/files/KJ00006020634.pdf"},"version_id":"740735fb-5c0d-4d18-87d6-0d3320c5016f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カルバマゼピンを服用中に急性リンパ性白血病を発症した3小児例(<特集>小児科学教室大澤真木子教授開講5周年記念)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カルバマゼピンを服用中に急性リンパ性白血病を発症した3小児例(<特集>小児科学教室大澤真木子教授開講5周年記念)"}]},"item_type_id":"10001","owner":"3","path":["1949"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"17900","relation_version_is_last":true,"title":["カルバマゼピンを服用中に急性リンパ性白血病を発症した3小児例(<特集>小児科学教室大澤真木子教授開講5周年記念)"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:55:42.675079+00:00"}