{"created":"2023-06-20T16:58:49.250315+00:00","id":17703,"links":{},"metadata":{"_buckets":{"deposit":"cc50265f-103f-439c-90fc-d6cbb7339bcd"},"_deposit":{"created_by":3,"id":"17703","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17703"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00017703","sets":["140:1307:1308:1934:1943"]},"author_link":["263314","263313","263311","263312"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"手術侵襲による細胞性免疫能の低下とそれに対するPSKの効果について"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"722","bibliographicPageStart":"715","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HIRAI, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OGAWA, Kenji"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"手術侵襲による生体反応の一つに細胞性免疫能の低下がある.生体に手術侵襲が加われば,内分泌系ホルモン,サイトカイン,急性相反応物質などが変生されて多彩な反応が引き起こされ,それらの複雑な作用により細胞性免疫能は低下する.著者らは,その発現のメカニズムとそれに対するPSK(protein-bound polysaccharide Kureha)の術前投与の効果について実験的に検討した.まずメカニズムについて,手術侵襲によって副腎皮質ホルモンのコルテゾールや急性相反応物質である免疫抑制性酸性蛋白が血液中に放出されることが確認された.これら免疫抑制因子によって宿主の免疫担当細胞の機能は傷害され,細胞性免疫能は低下すると考えられる.次にPSKの効果についてみると,その術前投与によってコルテゾールや免疫抑制性酸性蛋白の過剰な産生が抑えられ,その結果,手術侵襲による細胞性免疫能の低下も防止できると考えられた.がんを手術する場合,こうした術中から術後の細胞性免疫能低下を防止することは腫瘍の増殖や転移形成との関連から重要であるが,biological response modifier (BRM ; 生物学的応答調節剤)の一つであるPSKの術前投与によって防止しうることが示唆された.","subitem_description_type":"Abstract"},{"subitem_description":"Suppression of cellular immunity is one of the biological responses of hosts exposed to surgical stress. Surgical stress causes secretion of adrenal corticosteroids, as well as the production of cytokines and acute phase reactants. These factors are involved in the complex mechanism by which cellular immunosuppression is induced. The mechanism of cellular immunosuppression and the effect of preoperative treatment with protein-bound polysaccharide Kureha (PSK), a biological response modifier (BRM) were investigated in an animal model. In this model, cortisol and immunosuppressive acidic protein (TAP) levels were increased by surgical stress, resulting in the suppression of cellular immunity. The immunosuppressive effects of cortisol and ZAP appeared to play an important role in the mechanism of immunosuppression due to surgical stress. In an attempt to minimize such immunosuppression, we treated rats with PSK preoperatively. PSK therapy was effective in suppressing the oversecretion of cortisol and the overproduction of IAP, and thereby prevent the postoperative impairment of cellular immunity. When malignant tumors are treated surgically, the cellular immunosuppression caused by surgical stress may assist the residual cancer cells to grow and metastasize. In this context, preoperative treatment with PSK may be useful to minimize such immunosuppression.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"263313","nameIdentifierScheme":"WEKO"}],"names":[{"name":"平井, 雅倫"}]},{"nameIdentifiers":[{"nameIdentifier":"263314","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小川, 健治"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Surgery, Tokyo Women's Medical University Daini Hospital"},{"subitem_text_value":"Department of Surgery, Tokyo Women's Medical University Daini Hospital"},{"subitem_text_value":"東京女子医科大学附属第二病院外科"},{"subitem_text_value":"東京女子医科大学附属第二病院外科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006020992.pdf","filesize":[{"value":"686.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006020992.pdf","url":"https://twinkle.repo.nii.ac.jp/record/17703/files/KJ00006020992.pdf"},"version_id":"df358c4e-efd9-44c3-9b88-b1ecbdf0dad1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Suppression of Cellular Immunity by Surgical Stress and Effect of PSK","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suppression of Cellular Immunity by Surgical Stress and Effect of PSK"}]},"item_type_id":"10001","owner":"3","path":["1943"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"17703","relation_version_is_last":true,"title":["Suppression of Cellular Immunity by Surgical Stress and Effect of PSK"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T22:43:17.965201+00:00"}