@article{oai:twinkle.repo.nii.ac.jp:00017605,
 author = {NAKAGAWA, Takao and SUGA, Hiroyasu and MIYOSHI, Norio and IMAMURA, Yoshiaki and FUKUDA, Masaru and DEGUCHI, Yoshizumi and SUZUKI, Tadashi},
 issue = {7/8},
 journal = {東京女子医科大学雑誌},
 month = {Aug},
 note = {外傷に関連したDICの実験動物モデルを作製する目的で,ラットに出血性侵襲を加え,血小板・凝固線溶系,サイトカインレベルおよび組織病理学的所見について,DICの発症を検討した.外傷,出血等の生体侵襲は,生体に産生,遊離される炎症性サイトカインを介してSIRSの病態を発現させるが,このサイトカインが血管内皮に作用する時,組織因子を遊離して,外因性凝固反応が始動されることになるので,出血により顕著なサイトカインの産生の見られた動物実験の報告に準拠して,ラットに出血性侵襲を加えた時の影響について検討した.血小板・凝固線溶系の変化は,松田のDIC診断基準によりDICに相当する数値であり,DICに特徴的な組織病理学的所見と併せて,DICの発症を確認し得た.サイトカインも有意な増加が認められた.エンドトキシン投与ラットにおいても同様な結果が得られてDICの発症を確認した.この出血性侵襲の方法は簡便であり,侵襲を量的に規定できることも利点であり,外傷に関連したDIC動物モデルとしても使用し得ると考える., In order to produce an experimental animal model of disseminated intravascular coagulation (DIG) related to traumas, rats were subjected to hemorrhage and the onset of DIG was investigated in terms of platelet count, Coagulofibrinolytic activity, cytokine levels, and histopathological findings following hemorrhage. Biological invasion, including trauma and hemorrhage, induces systemic inflammatory response syndrome (SIRS) through inflammatory cytokines produced and released in the body. When these cytokines affect the vascular endothelium, tissue factor is released and exogenous coagulation is instituted. We investigated the effects of hemorrhage in rats, based on an animal experiment report of marked cytokine production occurring after hemorrhage. Changes in platelet count and the Coagulofibrinolytic system showed values corresponding to DIG on the basis of Matsuda's DIG diagnostic standards. Histopathological findings characteristic of DIG together with these changes enabled the onset of DIG to be identified. Cytokine levels also increased significantly. Similar results were obtained in rats administered endotoxin, and as a consequence, the onset of DIG was confirmed. This simple and easy hemorrhage method has the advantage of allowing invasion to be determined quantitatively as well. We anticipate that this method will be useful as a trauma-related DIG animal model.},
 pages = {396--403},
 title = {Experimental Study on the Onset of Traumatic Disseminated Intravascular Coagulation : Changes in the Coagulofibrinolytic System, Blood Cytokine Levels and Histopathological Findings Following Hemorrhage in Rats},
 volume = {69},
 year = {1999}
}