{"created":"2023-06-20T16:58:33.782976+00:00","id":17352,"links":{},"metadata":{"_buckets":{"deposit":"8627beb0-5af3-41cf-883d-a84f9886dbac"},"_deposit":{"created_by":3,"id":"17352","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17352"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00017352","sets":["140:1307:1308:1934:1935"]},"author_link":["262257","262258"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Fas/Fas Ligand System of Lymphocytes in Patients with Behget Disease"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-01-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"28","bibliographicPageStart":"21","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小笠原, 勝則"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The expression of Fas antigen, Fas sensitivity, soluble Fas (sFas) and soluble Fas ligand (sFasL) levels were examined to investigate the role of the Fas/Fas ligand system in the pathogenesis of Behget Disease (BD). The expression of Fas antigen was examined by flow cytometry, and the Faspositive rate of peripheral blood mononuclear cells in BD patients (n=12) was significantly higher than that in normal controls (NCsi n=8, p<0.05). Furthermore, the Fas-positive rate was significantly suppressed in BD patients who used immunosuppressants (n=10, p<0.05). The Fas sensitivities of peripheral T cells to anti-Fas monoclonal antibody were evaluated by cell counting and trypan blue exclusion. The sensitivities in BD patients (n=12) was significantly increased compared to those in NCs (n=12, p<0.005). Quantification of sFas and sFasL was performed by the sandwich ELISA method. The sFas level of BD patients in the inactive stage (3.74 ng/ml, n=38) was significantly increased compared to the early-active stage (2.14 ng/ml, n=17) and to NCs (1.93 ng/ml, n=15). No significant difference in sFasL levels was found between the stages of BD and NCs. Some disorders of Fas/Fas ligand system in BD were revealed in this study, which may pertain to the inflammatory mechanism in BD.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"262258","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OGASAWARA, Katsunori"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学附属第二病院眼科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006020700.pdf","filesize":[{"value":"666.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006020700.pdf","url":"https://twinkle.repo.nii.ac.jp/record/17352/files/KJ00006020700.pdf"},"version_id":"b8274492-82b2-4109-b39d-12c8967bc46a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ベーチェット病患者リンパ球におけるFas/Fasリガンドシステムの発現に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ベーチェット病患者リンパ球におけるFas/Fasリガンドシステムの発現に関する検討"}]},"item_type_id":"10001","owner":"3","path":["1935"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"17352","relation_version_is_last":true,"title":["ベーチェット病患者リンパ球におけるFas/Fasリガンドシステムの発現に関する検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T22:51:31.588059+00:00"}