{"created":"2023-06-20T16:58:21.408876+00:00","id":17074,"links":{},"metadata":{"_buckets":{"deposit":"143cdab8-15a5-4520-91c4-d4163102256a"},"_deposit":{"created_by":3,"id":"17074","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17074"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00017074","sets":["140:1307:1308:1924:1929"]},"author_link":["261600","261610","261608","261605","261595","261599","261601","261603","261604","261606","261609","261596","261594","261611","261597","261598","261607","261602"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pathophysiological Significance of Angiotensin II Receptor Subtype in Human Adrenals"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6/7","bibliographicPageEnd":"328","bibliographicPageStart":"321","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田辺, 晶代"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"成瀬, 光栄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"成瀬, 清子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉本, 貴宣"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"関, 敏郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三品, 直子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今城, 俊浩"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"曽, 正陪"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"出村, 博"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The adrenal gland is one of the major target organs of angiotensin II (Ang II). However, the pathophysiological significance of the Ang II receptor subtypes, AT1 and AT2, in human adrenals has not been elucidated. We investigated the mRNA expression of each receptor subtype and their role in steroid secretion in human adrenals. Expression levels of AT1 and AT2 receptor mRNA were determined by reverse transcription-polymerase chain reaction followed by Southern blot analysis of normal adrenocortical tissues (n=6) and several adrenal tumor tissues : aldosterone-producing adrenocortical adenoma (n=6), Cushing's syndrome (n=6), and pheochromocytoma (n=6). Steroid secretion was examined in vitro by incubating tissue with Ang II (1μM) or the selective AT2 agonist CGP-42112 (1μM) in the presence or absence of the selective AT1 antagonist CV-11974 (1μM). mRNA expression of both receptor subtypes was demonstrated in all human adrenal tissues examined. The expression levels of AT1 and AT2 mRNA tended to be higher in tumor tissues compared to normal tissues. Ang II-induced aldosterone secretion was suppressed 50% by the addition of CV-11974. CGP-42112 increased aldosterone secretion by 55% over the control, which was not suppressed by CV-11974. Incubation of adrenal tissues with Ang II or CGP-42112 did not affect cortisol secretion. These results suggest that AT2, as well as AT1, may be involved in the stimulation of aldosterone secretion and tumorigenesis of the human adrenals.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"261603","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TANABE, Akiyo"}]},{"nameIdentifiers":[{"nameIdentifier":"261604","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NARUSE, Mitsuhide"}]},{"nameIdentifiers":[{"nameIdentifier":"261605","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NARUSE, Kiyoko"}]},{"nameIdentifiers":[{"nameIdentifier":"261606","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YOSHIMOTO, Takanobu"}]},{"nameIdentifiers":[{"nameIdentifier":"261607","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SEKI, Toshiro"}]},{"nameIdentifiers":[{"nameIdentifier":"261608","nameIdentifierScheme":"WEKO"}],"names":[{"name":"MISHINA, Naoko"}]},{"nameIdentifiers":[{"nameIdentifier":"261609","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IMAKI, Toshihiro"}]},{"nameIdentifiers":[{"nameIdentifier":"261610","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ZENG, Zheng-Pei"}]},{"nameIdentifiers":[{"nameIdentifier":"261611","nameIdentifierScheme":"WEKO"}],"names":[{"name":"DEMURA, Hiroshi"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"},{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"},{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"},{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"},{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"},{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"},{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"},{"subitem_text_value":"北京協和医院内分泌研究中心"},{"subitem_text_value":"東京女子医科大学内分泌疾患総合医療センター"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006024617.pdf","filesize":[{"value":"819.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006024617.pdf","url":"https://twinkle.repo.nii.ac.jp/record/17074/files/KJ00006024617.pdf"},"version_id":"0049719a-ced4-4d83-9d6e-139fe592c4ce"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト副腎におけるアンジオテンシンII受容体サブタイプの病態生理学的意義に関する研究 : 岡本糸枝研究奨励金研究報告","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト副腎におけるアンジオテンシンII受容体サブタイプの病態生理学的意義に関する研究 : 岡本糸枝研究奨励金研究報告"}]},"item_type_id":"10001","owner":"3","path":["1929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"17074","relation_version_is_last":true,"title":["ヒト副腎におけるアンジオテンシンII受容体サブタイプの病態生理学的意義に関する研究 : 岡本糸枝研究奨励金研究報告"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T22:57:22.379456+00:00"}