{"created":"2023-06-20T16:58:18.048306+00:00","id":16997,"links":{},"metadata":{"_buckets":{"deposit":"95a91891-2526-41c0-9021-33dbc7e65086"},"_deposit":{"created_by":3,"id":"16997","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16997"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016997","sets":["140:1307:1308:1924:1928"]},"author_link":["261276","261271","261273","261274","261275","261272","261270","261277"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Evaluation of Improvement of Hepatic Fibrosis After Interferon Therapy for Chronic Hepatitis Type C"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-05-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"222","bibliographicPageStart":"215","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 春樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"富松, 昌彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大川, 真一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相羽, 元彦"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We studied the change of hepatic fibrosis after the cessation of interferon (IFN) therapy for chronic hepatitis type C in 46 patients. We stained biopsy specimens by Masson trichrome staining and immunohistochemical staining for type I・III・IV collagens, and classified the cases into 4 stages (F_0～F_3). The effect of IFN was correlated with quantity and genotype of HCV but not with a pathological stage. Hepatic fibrosis improved more significantly in responders than in non-responders in terms of both pathology and fibrogenesis serum markers. We concluded that IFN works indirectly on improvement of fibrosis by way of HCV clearance. Type I collagen was observed only in Glisson sheath. In F_1, but was additionally observed in the expanded fibrotic areas in F_2 and F_3. In improved cases, type III and type IV collagens appeared as pericellular fibrosis and thin septal fibrosis, with type I collagen was also present in the same area. These histological features may show the process of hepatic collagen degeneration.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"261274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAKAHASHI, Haruki"}]},{"nameIdentifiers":[{"nameIdentifier":"261275","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TOMIMATSU, Masahiko"}]},{"nameIdentifiers":[{"nameIdentifier":"261276","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OHKAWA, Shin-ichiro"}]},{"nameIdentifiers":[{"nameIdentifier":"261277","nameIdentifierScheme":"WEKO"}],"names":[{"name":"AIBA, Motohiko"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学附属第二病院内科"},{"subitem_text_value":"東京女子医科大学附属第二病院内科"},{"subitem_text_value":"東京女子医科大学附属第二病院内科"},{"subitem_text_value":"東京女子医科大学附属第二病院病理科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006024535.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006024535.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16997/files/KJ00006024535.pdf"},"version_id":"11d7647d-ec0e-4568-9be6-e44fc9578b16"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討"}]},"item_type_id":"10001","owner":"3","path":["1928"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16997","relation_version_is_last":true,"title":["C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T22:59:00.602569+00:00"}