@article{oai:twinkle.repo.nii.ac.jp:00016880,
 author = {斉藤, 理恵},
 issue = {12},
 journal = {東京女子医科大学雑誌},
 month = {Dec},
 note = {Melatonin is involved in the onset of puberty, and is considered to suppress the functions of reproductive organs. To investigate diurnal changes in serum melatonin, LH, FSH, prolactin and estradiol levels in pubertal patients with menstrual disorders and age-matched normal females, we determined the serum levels of these hormones every 2 hours for 24 hours. The area under curve (AUC) of nocturnal serum melatonin levels in patients with menstrual disorders was significantly higher than that of normal controls. After clomiphene treatment of the secondary amenorrheic patients, the AUC of serum melatonin was lower in the ovulation subgroup than in the anovulation subgroup. Although the estadiol level in the ovulation group was marginally higher than in the anovulation group, there was a negative correlation between the serum estradiol level and serum melatonin in the anovulation subgroup. To study this correlation, we treated 5 week-old female Wistar-Imamichi strain rats with FSH and determined serum estradiol levels and the pineal melatonin content 48 hours later. FSH increased serum estradiol levels while decreasing the melatonin content of the pineal body. This FSH effect was reversed by coadministration of an aromatase inhibitor. Again, there was a negative correlation between serum estradiol levels and the pineal body melatonin content in rats. These results suggest that the high melatonin levels observed in patients with menstrual disorders were decreased by induction of ovulation through increasing serum estradiol levels.},
 pages = {1106--1113},
 title = {思春期の排卵障害とメラトニン分泌動態},
 volume = {67},
 year = {1997}
}