{"created":"2023-06-20T16:58:12.428062+00:00","id":16868,"links":{},"metadata":{"_buckets":{"deposit":"3c844494-68e0-4dc5-a99b-7e84a4253553"},"_deposit":{"created_by":3,"id":"16868","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16868"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016868","sets":["140:1307:1308:1912:1923"]},"author_link":["260886","260883","260885","260882","260887","260884"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Involvement of the Antithrombotic Function in the Chorionic Villi with the Onset of Intrauterine Growth Retardation"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"982","bibliographicPageStart":"973","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中谷, 明子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中林, 正雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武田, 佳彦"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is suggested that a hemoconcentration and hypercoagulation are strongly related to the onset of intrauterine growth retardation (IUGR) through the deterioration of the placental circulation. The chorionic villi in the placenta will maintain the microcirculation and fetomaternal transportation in the placenta by its strong anticoagulant activity, which is affected with maternal blood hypercoagulation. In this study, two kinds of anticoagulant (maltose-heparin (M-H) or antithrombin III (ATIII)) were given to pregnant women with IUGR. The patients were divided into two groups according to their maternal hematocrit (Hct) levels, a normal Hct (N-H) group (32.4 ± 1.3%, mean ± SE) and a high Hct (H-H) group (40.0 ± 0.5%). The M-H therapy was effective in the N-H group (the increment of estimated fetal body weight measured by ultrasound was 26.6 ± 3.7 g/day), but it was not effective in the H-H group (11.1 ± 2.1 g/day), while the ATIII therapy was effective in the H-H group (20.6 ± 4.0 g/day). To clarify the effects of ATIII on the placental circulation, the culture system of chorionic villi was applied. By the addition of ATIII to the culture medium, the production and release of prostacyclin by villous cells and the contents of cellular thrombomodulin, which acts as an inhibitor of thrombin, which acts as an inhibitor of thrombin, were significantly increased. It is suggested that ATIII therapy will improve placental circulation through the increase of anticoagulant activity in the chorionic villi, all of which result in the improvement of IUGR.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"260885","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKATANI, Akiko"}]},{"nameIdentifiers":[{"nameIdentifier":"260886","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKABAYASHI, Masao"}]},{"nameIdentifiers":[{"nameIdentifier":"260887","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAKEDA, Yoshihiko"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学産婦人科学教室"},{"subitem_text_value":"東京女子医科大学母子総合医療センター"},{"subitem_text_value":"東京女子医科大学産婦人科学教室"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025283.pdf","filesize":[{"value":"849.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025283.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16868/files/KJ00006025283.pdf"},"version_id":"657bad1e-6fef-4029-9c27-b7c73470ab25"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"子宮内胎児発育遅延における絨毛の抗血栓機能の意義に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮内胎児発育遅延における絨毛の抗血栓機能の意義に関する研究"}]},"item_type_id":"10001","owner":"3","path":["1923"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16868","relation_version_is_last":true,"title":["子宮内胎児発育遅延における絨毛の抗血栓機能の意義に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:01:50.952721+00:00"}