{"created":"2023-06-20T16:58:12.296083+00:00","id":16865,"links":{},"metadata":{"_buckets":{"deposit":"4b935ce5-e749-4816-9d6f-fc87c1f1adef"},"_deposit":{"created_by":3,"id":"16865","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16865"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016865","sets":["140:1307:1308:1912:1923"]},"author_link":["260872","260873"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Immunohistochemical Study of the Estrogen Receptor and Ki-67 Expression in Endometrial Carcinoma"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1062","bibliographicPageStart":"1054","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菊地, 愛子"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the tumors of fifty-eight patients with endometrial carcinoma by immunohistochemical analysis of estrogen receptor (ER) expression and Ki-67 labeling index (L.I.). In twenty-four patients we also performed a biochemical analysis of ER. The results were as follows. 1) There was a good correlation between the immunohistochemical categories and biochemical levels of ER. 2) The presence of ER was significantly (p <0.05) associated with surgical stage, but was not related to histologic differentiation. 3) In the ER-negative group, Ki-67 L.I. was significantly (p <0.05) associated with surgical stage, histologic differentiation, lymph-node metastasis, ductal permeation and recurrence, Ki-67 may become a prognostic marker in this group of patients. 4) In the premenopausal patients who had ER, the level of Ki-67 was significantly higher (p <0.01) than the ER-negative premenopausal patients. Our results suggest that the proliferative effect of the endogenous estrogen on endometrial carcinoma affects the Ki-67 levels in the ER-positive group, where as some extra-estrogenic factor such as an oncogene may affect the elevated Ki-67 levels in the ER-negative group. Immunohistochemical analysis of ER status with Ki-67 L.I. is not only simple and practical, but also predicts the degree of malignancy.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"260873","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KIKUCHI, Aiko"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学産婦人科学教室"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025293.pdf","filesize":[{"value":"977.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025293.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16865/files/KJ00006025293.pdf"},"version_id":"711cdbc4-442b-4b9f-ab14-5225e479b8dc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"子宮体癌におけるエストロゲンレセプターの発現と抗Ki-67抗体を用いた細胞増殖能についての免疫組織化学的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮体癌におけるエストロゲンレセプターの発現と抗Ki-67抗体を用いた細胞増殖能についての免疫組織化学的検討"}]},"item_type_id":"10001","owner":"3","path":["1923"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16865","relation_version_is_last":true,"title":["子宮体癌におけるエストロゲンレセプターの発現と抗Ki-67抗体を用いた細胞増殖能についての免疫組織化学的検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:01:54.623756+00:00"}