{"created":"2023-06-20T16:58:12.252802+00:00","id":16864,"links":{},"metadata":{"_buckets":{"deposit":"ea2910cd-53bd-482d-b26d-a73955728158"},"_deposit":{"created_by":3,"id":"16864","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16864"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016864","sets":["140:1307:1308:1912:1923"]},"author_link":["260864","260871","260869","260867","260865","260868","260870","260866"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Interleukin-8 Production of Neutrophils and Inhibitory Effects of FK506 in Behcet's Disease"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1048","bibliographicPageStart":"1041","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"八木, 郁子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小暮, 美津子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西川, 恵"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相川, 英三"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"While the etiology of Behcet's disease is still unknown, it is believed that functional abnormalities of neutrophils, such as increases in the migration and production of active oxygen, are intimately involved in the pathogenesis of the disease. This study was undertaken to examine the interleukin-8 (IL-8) production of peripheral neutrophils, focusing on the fact that the IL-8 activates neutrophil migration and enhances their function, and to examine the inhibitory effects of FK506 (an immunosuppressive agent) on neutrophil production of IL-8. Peripheral neutrophil specimens were collected from patients with Behcet's disease and healthy persons, and divided into a group stimulated by lipopolysaccharide (LPS) (LPS-stimulated group) and a group not stimulated by it (non-stimulated group). IL-8 secretion was measured in the both groups to assess the expression of IL-8 mRNA. In addition, FK506 was added to the LPS-stimulated culture to measure IL-8 secretion by neutrophils. The results showed increased neutrophil production of IL-8 in the Behcet's disease group and expression of IL-8 mRNA even in the non-stimulated group. The IL-8 production was shown to be inhibited by FK506. These findings suggest that Behcet's disease is associated with in vivo priming of peripheral neutrophils, implying that IL-8 produced by neutrophils plays a role in the pathogenesis of Behcet's disease. In addition, FK506 may have an inhibitory effection neutrophil IL-8 production as a mechanism in Behcet's disease.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"260868","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YAGI, Ikuko"}]},{"nameIdentifiers":[{"nameIdentifier":"260869","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KOGURE, Mitsuko"}]},{"nameIdentifiers":[{"nameIdentifier":"260870","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NISHIKAWA, Megumi"}]},{"nameIdentifiers":[{"nameIdentifier":"260871","nameIdentifierScheme":"WEKO"}],"names":[{"name":"AIKAWA, Eizo"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学眼科学教室"},{"subitem_text_value":"東京女子医科大学眼科学教室"},{"subitem_text_value":"東京女子医科大学解剖学・発生生物学教室"},{"subitem_text_value":"東京女子医科大学解剖学・発生生物学教室"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025291.pdf","filesize":[{"value":"721.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025291.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16864/files/KJ00006025291.pdf"},"version_id":"2abd2299-bac2-42f1-9e11-cc6b379ebbe0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ベーチェット病における好中球のインターロイキン-8産生能とFK506による産生抑制","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ベーチェット病における好中球のインターロイキン-8産生能とFK506による産生抑制"}]},"item_type_id":"10001","owner":"3","path":["1923"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16864","relation_version_is_last":true,"title":["ベーチェット病における好中球のインターロイキン-8産生能とFK506による産生抑制"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:01:56.206158+00:00"}