{"created":"2023-06-20T16:58:11.773523+00:00","id":16853,"links":{},"metadata":{"_buckets":{"deposit":"9fb88336-55b4-4d3c-9441-81ff1e9e10bb"},"_deposit":{"created_by":3,"id":"16853","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16853"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016853","sets":["140:1307:1308:1912:1922"]},"author_link":["260841","260834","260833","260837","260840","260836","260842","260838","260839","260835"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Immunofluorescence Study of Complement Regulatory Proteins in Irises from Patients with Behcet's Disease"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-11-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"943","bibliographicPageStart":"937","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"呉, 朋子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小暮, 美津子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"陳, 麗理"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西川, 恵"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相川, 英三"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although it's known that complement regulatory proteins, which protect self-cells from activation of the complement, spread widely in a living body, we haven't had any reports about the existence of them in the human iris yet. In this study, we used an Immunofluorescence technique and investigated the expression of C3bC4b receptor (CR1), membrane cofactor protein (MCP) and decay accelerating factor (DAF), which inhibit activation of C3, and homologous restriction factor 20 (HRF20), which inhibits activation of C9, in irises from 7 patients with Behcet's disease and 7 patients with glaucoma but without uveitis as controls. CR1, MCP and DAF weren't observed in any patients. HRF20 was expressed on endothelial cells of vessels, iris stroma and iris pigment epithelium in all patients. Comparing the patients and the controls, revealed no significant differences. From these results, we propose as for activation of the complement system in the human iris, acceleration of vascular permeability and chemotactic activity of polymorphonuclear leucocytes, which are caused by activation of C3, occur easily and that cytolysis, which is caused by activation of C9, hardly occurs. We also propose the result that the less existence of complement regulatory proteins in the patients concerns the pathogenesis of the disease.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"260838","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KURE, Tomoko"}]},{"nameIdentifiers":[{"nameIdentifier":"260839","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KOGURE, Mitsuko"}]},{"nameIdentifiers":[{"nameIdentifier":"260840","nameIdentifierScheme":"WEKO"}],"names":[{"name":"CHEN, Li-Li"}]},{"nameIdentifiers":[{"nameIdentifier":"260841","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NISHIKAWA, Megumi"}]},{"nameIdentifiers":[{"nameIdentifier":"260842","nameIdentifierScheme":"WEKO"}],"names":[{"name":"AIKAWA, Eizo"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学眼科学教室"},{"subitem_text_value":"東京女子医科大学眼科学教室"},{"subitem_text_value":"東京女子医科大学眼科学教室"},{"subitem_text_value":"東京女子医科大学解剖学・発生生物学教室"},{"subitem_text_value":"東京女子医科大学解剖学・発生生物学教室"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025248.pdf","filesize":[{"value":"708.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025248.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16853/files/KJ00006025248.pdf"},"version_id":"4e91a17d-2f88-4107-a142-89076573c030"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ベーチェット病患者の虹彩における補体制御因子の免疫組織学的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ベーチェット病患者の虹彩における補体制御因子の免疫組織学的検討"}]},"item_type_id":"10001","owner":"3","path":["1922"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16853","relation_version_is_last":true,"title":["ベーチェット病患者の虹彩における補体制御因子の免疫組織学的検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:02:17.429616+00:00"}