{"created":"2023-06-20T16:58:10.059567+00:00","id":16814,"links":{},"metadata":{"_buckets":{"deposit":"8bf37a2b-511c-4e68-ba3f-b72c1f13e0c1"},"_deposit":{"created_by":3,"id":"16814","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16814"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016814","sets":["140:1307:1308:1912:1921"]},"author_link":["260691","260688","260689","260685","260694","260692","260687","260690","260693","260686"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Long-term Effect of Interferon Therapy for Chronic Hepatitis C"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9/10","bibliographicPageEnd":"828","bibliographicPageStart":"821","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中島, 博子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"富松, 昌彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋, 春樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡野, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森, 治樹"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ninety-four patients with chronic hepatitis C treated with interferon (IFN) were followed up clinically, histologically, and virologically for more than one year after the completion of treatment. The complete responder group (CR) comprised 34 cases (36.2%) in whom HCV-RNA was cleared from serum at least 6 months after treatment. Twenty-nine of the CRs (85%) showed improvements in histology and alanine aminotransferase (ALT) levels. However, even among the 60 non-complete responders (NCR) in whom serum HCV-RNA was detected after treatment, 10 cases (16.7%) showed normalization of ALT levels. The patients infected with HCV of genotype II showed higher serum HCV-RNA levels than those infected wtih genotypes III and IV. HCV-RNA levels tended to be lower in CRs than in NCRs. Before treatment, 52.9% of CRs were histologically diagnosed as CAH-2A, 2 of whom were diagnosed as cirrhosis. Hepatocellular carcinomas were detected in 3 cases (3.2%) after treatment, two of whom were CRs. These results suggest that improvements in histology and ALT levels could be obtained in CR cases, but that long-term follow-up with imaging and other examination techniques is necessary.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"260690","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKAJIMA, Hiroko"}]},{"nameIdentifiers":[{"nameIdentifier":"260691","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TOMIMATSU, Masahiko"}]},{"nameIdentifiers":[{"nameIdentifier":"260692","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAKAHASHI, Haruki"}]},{"nameIdentifiers":[{"nameIdentifier":"260693","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OKANO, Akira"}]},{"nameIdentifiers":[{"nameIdentifier":"260694","nameIdentifierScheme":"WEKO"}],"names":[{"name":"MORI, Haruki"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学第二病院内科II"},{"subitem_text_value":"東京女子医科大学第二病院内科II"},{"subitem_text_value":"東京女子医科大学第二病院内科II"},{"subitem_text_value":"東京女子医科大学第二病院内科II"},{"subitem_text_value":"東京女子医科大学第二病院内科II"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025213.pdf","filesize":[{"value":"631.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025213.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16814/files/KJ00006025213.pdf"},"version_id":"edc4b125-ad1c-460d-ae58-6c2f2a62fcb6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"C型慢性肝炎のインターフェロン療法と長期予後","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C型慢性肝炎のインターフェロン療法と長期予後"}]},"item_type_id":"10001","owner":"3","path":["1921"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16814","relation_version_is_last":true,"title":["C型慢性肝炎のインターフェロン療法と長期予後"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:03:14.842200+00:00"}