{"created":"2023-06-20T16:58:06.585562+00:00","id":16734,"links":{},"metadata":{"_buckets":{"deposit":"7a75561c-bd2e-4573-a23c-cc82d66c8460"},"_deposit":{"created_by":3,"id":"16734","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16734"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016734","sets":["140:1307:1308:1912:1920"]},"author_link":["260540","260539","260542","260545","260538","260537","260541","260547","260546","260536","260544","260543"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"B型肝炎ウイルスpre-S2領域の分類とその臨床応用 : HLA-A24により提示されるpre-S2ペプチドの慢性肝炎の発症における役割"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"525","bibliographicPageStart":"519","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YONEMITSU, Harumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAUCHI, Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOKUSHIGE, Katsutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Naoaki"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"B型肝炎ウイルス(HBV)は,その持続感染にも関わらず肝細胞障害を起こすことのない無症候性キャリアが存在することから,宿主の免疫反応,とりわけキラーT細胞(CTL)が肝障害の主役を担っていると考えられているが,その詳細についてはよくわかっていない.我々は,pre-S2領域の開始より39塩基にわたる部分は変化に富む領域で,これらの変異のパターンをHBs抗原のサブタイプ別のpre-S2配列との類似性より大きくI型,II型,III型pre-S2の3型に分類できることを明らかにした.今回は,これらのpre-S2型の分類に有用な新しいPCR法を開発し,以下の事実を明らかにできた.血清トランスアミナーゼ値が高値で1型pre-S2ウイルス感染患者の32例中27例がHLA-A24保持者であるのに対し,血清トランスアミナーゼ値が半年以上正常な患者では上記のような相関は見られなかった.また,HLA-A24を持つ患者において,血清トランスアミナーゼ値が高い時に見られた1型pre-S2HBVがALT値の低下に伴い異なった型のpre-S2を持っHBVへ転換する現象が多く見られた.この事実は,少なくとも,HLA-A24を有する患者において,肝細胞障害が発現するためには,I型pre-S2HBVの存在が重要な意味を持っていることを示している.","subitem_description_type":"Abstract"},{"subitem_description":"The pre-S2 region of the hepatitis B virus (HBV) was classified into three types according to their nucleotide sequences. We attempted to determine these pre-S2 types by polymerase chain reaction (PCR), using specific primers prepared from the first 39 nucleotides of the pre-S2 region and found that quite similar results were obtained for sequencing studies and PCR. Subsequently, we examined the pre-S2 type in 45 HBV-infected chronic hepatitis B patients together with HLA class I phenotype and disease activity. The HLA-A24 antigen was found in 27 of 32 type I pre-S2 HBV-infected patients with active hepatitis, whereas none of 6 patients with inactive disease had HLA-A24. Serial studies in 13 patients with HLA-A24 showed that with remission of hepatitis, clearance of type I pre-S2 HBV was seen in all patients. These results suggest that HLA-A24 expression in the setting of type I pre-S2 HBV infection may play a role in the pathogenesis of chronic hepatitis B.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"260542","nameIdentifierScheme":"WEKO"}],"names":[{"name":"米満, 春美"}]},{"nameIdentifiers":[{"nameIdentifier":"260543","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山内, 克巳"}]},{"nameIdentifiers":[{"nameIdentifier":"260544","nameIdentifierScheme":"WEKO"}],"names":[{"name":"清水, 健"}]},{"nameIdentifiers":[{"nameIdentifier":"260545","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中村, 哲夫"}]},{"nameIdentifiers":[{"nameIdentifier":"260546","nameIdentifierScheme":"WEKO"}],"names":[{"name":"徳重, 克年"}]},{"nameIdentifiers":[{"nameIdentifier":"260547","nameIdentifierScheme":"WEKO"}],"names":[{"name":"林, 直諒"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"東京女子医科大学消化器病センター内科"},{"subitem_text_value":"東京女子医科大学消化器病センター内科"},{"subitem_text_value":"東京女子医科大学消化器病センター内科"},{"subitem_text_value":"東京女子医科大学消化器病センター内科"},{"subitem_text_value":"東京女子医科大学消化器病センター内科"},{"subitem_text_value":"東京女子医科大学消化器病センター内科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025362.pdf","filesize":[{"value":"562.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025362.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16734/files/KJ00006025362.pdf"},"version_id":"c3b0c084-02ca-45ea-8b9a-4492049e6e1d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CLINICAL IMPLICATIONS OF HEPATITIS B VIRUS pre-S2 TYPE : A POSSIBLE ROLE FOR pre-S2 PEPTIDE PRESENTATION BY HLA-A24 IN CHRONIC HEPATITIS B PATHOGENESIS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CLINICAL IMPLICATIONS OF HEPATITIS B VIRUS pre-S2 TYPE : A POSSIBLE ROLE FOR pre-S2 PEPTIDE PRESENTATION BY HLA-A24 IN CHRONIC HEPATITIS B PATHOGENESIS"}]},"item_type_id":"10001","owner":"3","path":["1920"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16734","relation_version_is_last":true,"title":["CLINICAL IMPLICATIONS OF HEPATITIS B VIRUS pre-S2 TYPE : A POSSIBLE ROLE FOR pre-S2 PEPTIDE PRESENTATION BY HLA-A24 IN CHRONIC HEPATITIS B PATHOGENESIS"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:05.131301+00:00"}