{"created":"2023-06-20T16:57:55.094905+00:00","id":16475,"links":{},"metadata":{"_buckets":{"deposit":"9cf7cb5f-2a1f-4169-a608-6f4ae7bbf6cd"},"_deposit":{"created_by":3,"id":"16475","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16475"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016475","sets":["140:1307:1308:1912:1915"]},"author_link":["259760","259759"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Airway Dysfunction and Ion Channel(Topics in internal medicine of cardiopulmonary system,Symposium)"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-04-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"237","bibliographicPageStart":"232","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"玉置, 淳"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Increased production of sputum and the difficulty in expectoration are frequently seen in patients with chronic respiratory diseases, but the mechanism of these airway dysfunction remains poorly understood. It has recently been shown that long-term administration of macrolide antibiotics is effective in the treatment of chronic airway infections including diffuse panbronchiolitis, chronic bronchitis and bronchiectasis. Erythromycin causes a remarkable reduction of sputum probably through a mechanism other than its antimicrobial property. To assess whether erythromycin directly inhibits airway secretory responses, we studied bioelectric properties of canine tracheal mucosa under short-circuit condition in vitro and open-circuit condition in vivo. Addition of erythromycin decreased short-circuit current of cultured tracheal epithelial cells and Cl-diffusion potential difference across the tracheal mucosa in a dose-dependent manner. These results suggest that macrolide can inhibit Cl channel opening and subsequent secretion of Cl and water toward the lumen, and that this mechanism may be operating in the efficacy of the drug in patients with aiway hypersecretion.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"259760","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAMAOKI, Jun"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学第一内科学"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025033.pdf","filesize":[{"value":"433.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025033.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16475/files/KJ00006025033.pdf"},"version_id":"e0735400-f14d-4dbf-ae25-a16e40b28c7d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"気道病態とイオンチャネル(イオンチャネルと病態,シンポジウム,<特集>東京女子医科大学学会第62回総会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"気道病態とイオンチャネル(イオンチャネルと病態,シンポジウム,<特集>東京女子医科大学学会第62回総会)"}]},"item_type_id":"10001","owner":"3","path":["1915"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16475","relation_version_is_last":true,"title":["気道病態とイオンチャネル(イオンチャネルと病態,シンポジウム,<特集>東京女子医科大学学会第62回総会)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:10:14.215631+00:00"}