@article{oai:twinkle.repo.nii.ac.jp:00016472, author = {萩原, 誠久 and 田村, 光司 and 庄田, 守男 and 松田, 直樹 and 梶本, 克也 and 坂井, 理映子 and 笠貫, 宏 and 細田, 瑳一}, issue = {4}, journal = {東京女子医科大学雑誌}, month = {Apr}, note = {Stretch-activated current was studied in rabbit sino-atrial node cells using the whole-cell patch clamp method. With continuous application of positive pressure through the patch electrode, the cell was inflated and the membrane conductance was increased. The stretch-activated current showed time-independent and outward rectifying properties and the current was sensitively reduced by the Cl channel blockers, such as SITS, DNDS or 9-AC. The reversal potential of stretch-activated current was well explained by the equilibrium potential of Cl. These findings indicate that the stretch-activated current is Cl selective, and the results suggested that the stretch-activated Cl current may contribute to the positive chronotropic effect during mechanical stimulation in sino-atrial node cells.}, pages = {227--231}, title = {洞結節細胞における伸展活性化チャネルの役割(イオンチャネルと病態,シンポジウム,<特集>東京女子医科大学学会第62回総会)}, volume = {67}, year = {1997} }