{"created":"2023-06-20T16:57:51.539074+00:00","id":16396,"links":{},"metadata":{"_buckets":{"deposit":"4dcadba7-7a5b-454c-948b-4fb6b0d66cca"},"_deposit":{"created_by":3,"id":"16396","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16396"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016396","sets":["140:1307:1308:1902:1911"]},"author_link":["259488","259485","259486","259484","259483","259487"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Studies of Tolerance Induction Through Mixed Chimerism in Cynomolgus Monkeys : Method for Detection of Chimeric Cells and Effect of Thymic Irradiation on Induction of Tolerance"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1168","bibliographicPageStart":"1160","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"星野, 智昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河合, 達郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 和夫"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Study 1; To establish the method for the detection of chimerism in cynomologus monkeys, we tested cross reactivity of various anti-HLA monoclonal antibodies (mAb) to cynomolgus monkeys. In 29 mAb we tested, only three monoclonal anti-HLA antibodies crossreacted with lymphocytes of monkeys. With these mAb, chimeric cell can be detected up to 1% by flow cytometric analysis. Study 2; Utilizing the method we developed in study 1, we applied the regimen that induces mixed chimerism and skin graft tolerance in mice to renal allotransplantation of cynomolgus monkey. Regimen A includes non-lethal dose of total body irradiation (TBI), administration of anti-thymocyte globulin (ATG) for 3 days, donor bone marrow infusion and 45 days course of cyclosporine (CYA) administration. We added 7 Gy of thymic irradiation on day-6 in regimen B and on day-1 in regimen C. Although all monkeys in regimen A and B consistently developed chimerism, they rejected kidney allografts soon after stopping CYA. In contrast, 4 monkeys out of 5 failed to develop chimerism in regimen C, but renal allograft tolerance was induced in one monkey who developed chimerism in regimen C. In conclusion, the induction of chimerism is considered necessary but not sufficient for tolerance induction.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"259486","nameIdentifierScheme":"WEKO"}],"names":[{"name":"HOSHINO, Tomoaki"}]},{"nameIdentifiers":[{"nameIdentifier":"259487","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAWAI, Tatsuo"}]},{"nameIdentifiers":[{"nameIdentifier":"259488","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OTA, Kazuo"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京女子医科大学第三外科学教室"},{"subitem_text_value":"東京女子医科大学第三外科学教室"},{"subitem_text_value":"東京女子医科大学第三外科学教室"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025940.pdf","filesize":[{"value":"888.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025940.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16396/files/KJ00006025940.pdf"},"version_id":"6874506d-d479-4b21-91fd-936e2554163e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"同種サル腎移植におけるmixed chimerismによる免疫寛容導入についての研究 : chimerism検出法ならびに免疫寛容導入と胸腺照射に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"同種サル腎移植におけるmixed chimerismによる免疫寛容導入についての研究 : chimerism検出法ならびに免疫寛容導入と胸腺照射に関する研究"}]},"item_type_id":"10001","owner":"3","path":["1911"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16396","relation_version_is_last":true,"title":["同種サル腎移植におけるmixed chimerismによる免疫寛容導入についての研究 : chimerism検出法ならびに免疫寛容導入と胸腺照射に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:12:03.249987+00:00"}