{"created":"2023-06-20T16:57:35.341550+00:00","id":16031,"links":{},"metadata":{"_buckets":{"deposit":"8f4ce54b-88de-4798-9700-1a43939706cf"},"_deposit":{"created_by":3,"id":"16031","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16031"},"status":"published"},"_oai":{"id":"oai:twinkle.repo.nii.ac.jp:00016031","sets":["140:1307:1308:1902:1903"]},"author_link":["258513","258511","258512","258507","258508","258510","258515","258509","258514","258504","258506","258505"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"細菌性スーパー抗原に対するヒトおよびマウスT細胞の反応性の差異の解析"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-02-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"31","bibliographicPageStart":"20","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"東京女子医科大学雑誌"}]}]},"item_10001_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NISHIKAWA, Mizuho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAGI, Junji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAN, Xiao-Jie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OSHIMI, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIYAZAKI, Shun-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UCHIYAMA, Takehiko"}],"nameIdentifiers":[{}]}]},"item_10001_date_25":{"attribute_name":"受付日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-10","subitem_date_issued_type":"Created"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"スーパー抗原は通常のタンパク抗原とは異なり,アクセサリー細胞(A細胞)上のMHCクラスII分子に直接結合し,特定のT細胞レセプターβ鎖V領域(Vβ)を表現する大きなT細胞レパートリーと反応する.したがって,細菌性スーパー抗原は,ヒトおよびマウス末梢リンパ球に同様な強い活性化を惹き起こす.しかし,ある種の細菌性スーパー抗原staphylococcal enterotoxin B (SEB),SEC等では,マウス末梢リンパ球は,ヒト末梢リンパ球と比較して著しく低応答性である.この反応性の差が,T細胞自体の反応性の差によるものか,A細胞のアクセサリー活性の差によるものかは末だ明らかではない.細菌性スーパー抗原によるT細胞反応の強さを決定する因子を解明するため,同一T細胞を用いて,ヒトおよびマウスMHCクラスII分子陽性細胞の存在下でSEAおよびSEBに対する反応性を比較,検討した.その結果,SEBに対するヒトとマウス末梢リンパ球の反応性の差は,A細胞のアクセサリー活性の差に基づくことが示唆された.また,アクセサリー活性の差は,反応丁細胞内Ca^<++>濃度にも差を惹き起こすことから,T細胞活性化の初期から影響を与えているものと考えられた.細菌性スーパー抗原による生体異常反応は,異常に強いT細胞反応に起因すると考えられている.したがって,T細胞反応の強さがA細胞のレベルで決定することが明らかとなったことは,細菌感染症の制御の上で有用であると思われる.","subitem_description_type":"Abstract"},{"subitem_description":"Bacterial superantigens (SAGs) bind to major histocompatibility complex (MHC) class II molecules on accessory cells (AC) and stimulate T cells upon interaction with the Vβ portion of the T cell receptor (TCR). We have recently shown that bacterial SAGs produced by Staphylococcus aureus, Staphylococcal enterotoxin A (SEA), SEB, SEC, and toxic shock syndrome toxin-1 (TSST-1) can all stimulate human peripheral blood mononuclear cells (PBMC) at very minute doses of antigens (&ge;10^<-4> ng/ml). By contrast, when murine peripheral lymphocytes are used, SEs and TSST-1 have been segregated into two groups according to potency. SEA and TSST-1 are equally strong stimulators of murine peripheral lymphocytes (&ge;10^<-4> ng/ml), whereas the responses of murine peripheral lymphocytes to SEB and SEC require 10^3～10^4-fold greater doses. However, it is still unclear whether this difference between the murine and human responses to SEB and SEC is due to a difference in T cell responsiveness or a difference in the activity of AC. In this study, the response of identical murine T cell preparations to SEB showed a preference for human AC over murine AC. Thus, the results indicated that the difference in response to SEB is primarily due to a difference in the activity of AC. Futhermore, the Ca^<++> concentration of murine T cells responding to SEB presented by human AC was higher than that of those responding to SEB presented by murine AC, indicating that different accessory activity influences T cell activation from the early phase of signal transduction.","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"258510","nameIdentifierScheme":"WEKO"}],"names":[{"name":"西川, 瑞穂"}]},{"nameIdentifiers":[{"nameIdentifier":"258511","nameIdentifierScheme":"WEKO"}],"names":[{"name":"八木, 淳二"}]},{"nameIdentifiers":[{"nameIdentifier":"258512","nameIdentifierScheme":"WEKO"}],"names":[{"name":"厳, 小傑"}]},{"nameIdentifiers":[{"nameIdentifier":"258513","nameIdentifierScheme":"WEKO"}],"names":[{"name":"押味, 蓉子"}]},{"nameIdentifiers":[{"nameIdentifier":"258514","nameIdentifierScheme":"WEKO"}],"names":[{"name":"宮崎, 俊一"}]},{"nameIdentifiers":[{"nameIdentifier":"258515","nameIdentifierScheme":"WEKO"}],"names":[{"name":"内山, 竹彦"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東京女子医科大学学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00161368","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0040-9022","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_35":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical College:Department of Gastroenterology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Physiology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Physiology, Tokyo Women's Medical College"},{"subitem_text_value":"Department of Microbiology and Immunology, Tokyo Women's Medical College:Department of Infectious Diseases, Tokyo Women's Medical College:Institute of Laboratory Animals, Tokyo Women's Medical College"},{"subitem_text_value":"東京女子医科大学微生物学免疫学:東京女子医科大学消化器内科学"},{"subitem_text_value":"東京女子医科大学微生物学免疫学"},{"subitem_text_value":"東京女子医科大学微生物学免疫学"},{"subitem_text_value":"東京女子医科大学第二生理学"},{"subitem_text_value":"東京女子医科大学第二生理学"},{"subitem_text_value":"東京女子医科大学微生物学免疫学:東京女子医科大学感染対策科:東京女子医科大学実験動物中央施設"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"KJ00006025505.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006025505.pdf","url":"https://twinkle.repo.nii.ac.jp/record/16031/files/KJ00006025505.pdf"},"version_id":"7220420d-e442-44d2-a08f-22d4a7fac6ac"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"DIFFERENCE IN HUMAN AND MURINE T CELL RESPONSIVENESS TO STAPHYLOCOCCAL ENTEROTOXINS IS DETERMINED BY ACTIVITIES OF MHC CLASS II-POSITIVE CELLS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DIFFERENCE IN HUMAN AND MURINE T CELL RESPONSIVENESS TO STAPHYLOCOCCAL ENTEROTOXINS IS DETERMINED BY ACTIVITIES OF MHC CLASS II-POSITIVE CELLS"}]},"item_type_id":"10001","owner":"3","path":["1903"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-10"},"publish_date":"2010-08-10","publish_status":"0","recid":"16031","relation_version_is_last":true,"title":["DIFFERENCE IN HUMAN AND MURINE T CELL RESPONSIVENESS TO STAPHYLOCOCCAL ENTEROTOXINS IS DETERMINED BY ACTIVITIES OF MHC CLASS II-POSITIVE CELLS"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:19:54.452793+00:00"}