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ラット胃潰瘍に対する各種薬剤の創傷治癒効果についての病理組織学的比較 : 胃潰瘍の内視鏡的止血術におけるフィブリン接着剤とbFGFの有効性の検証
http://hdl.handle.net/10470/27996
http://hdl.handle.net/10470/279960458d05a-59b9-4e77-82e2-a1b2116226d1
名前 / ファイル | ライセンス | アクション |
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KJ00006015027.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | ラット胃潰瘍に対する各種薬剤の創傷治癒効果についての病理組織学的比較 : 胃潰瘍の内視鏡的止血術におけるフィブリン接着剤とbFGFの有効性の検証 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Histopathological Comparison of Wound Healing Effect of Various Drugs to Gastric Ulcer of Rat : Verification of Effectiveness of Endoscopic Hemostasis of Gastric Ulcer between the Fibrin Glue and bFGF | |||||
著者名 |
濱田, 隆光
× 濱田, 隆光× 中川, 隆雄× 須賀, 弘泰× 小林, 尊志× 今村, 好章 |
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著者別名 | ||||||
姓名 | HAMADA, Takamitsu | |||||
著者別名 | ||||||
姓名 | NAKAGAWA, Takao | |||||
著者別名 | ||||||
姓名 | SUGA, Hiroyasu | |||||
著者別名 | ||||||
姓名 | KOBAYASHI, Takashi | |||||
著者別名 | ||||||
姓名 | IMAMURA, Yoshiaki | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 78, 号 8/9, p. 448-453, 発行日 2008-08 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A number of patients who are brought to our emergency center suffer from complication of coagulation-fibrinolysis disorder and those patients who also suffer from gastrointestinal hemorrhage present a problem in endoscopic hemorrhagic control. Thus an experiment was conducted by using rat to find the hemostatic and tissue healing effects of fibrin glue and basic fibrinocyte growth factor (bFGF). Under Nembutal anesthesia, the rats were subjected to laparotomy to create mechanically hemorrhagic ulcers in the pyloric antrum. Into these lesions a physiological saline (sham), Bosmin in a hypertonic saline (HSE), ethanol (ET) or a fibrin glue (FG) was injected locally and their wound were closed. On the 1st, 3rd, 5th and 7th day following surgery, the abdomen was re-opened and pylorectomy was conducted for comparative evaluation of the local hemostatic and ulcer healing effects. FG was most effective in epithelial regeneration, remaining in the tissue until 7th day and suggesting its sustained hemostatic effect. Other groups showed some complications, such as mucosal and submucosal hemorrhage, inflammatory cell infiltration, poor epithelial development and others. The FG local injection therapy results in satisfactory epithelial regeneration: in addition to its hemostatic effect, the wound healing effect may be expected from the combination with bFGF. | |||||
著者所属 | ||||||
東京女子医科大学東医療センター救急医療科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター救急医療科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター救急医療科 | ||||||
著者所属 | ||||||
東京女子医科大学東医療センター救急医療科 | ||||||
著者所属 | ||||||
福井大学医学部附属病院病理 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | hemorrhagic gastric ulcer | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | endoscopic hemostasis | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | wound healing | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | basic fibroblast growth factor | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | fibrin glue |