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腋窩リンパ節転移陽性乳癌における原発巣とリンパ節転移巣のHER2発現状況についての検討
http://hdl.handle.net/10470/27844
http://hdl.handle.net/10470/27844d655a154-e508-422f-804b-2a505dc3cc0d
名前 / ファイル | ライセンス | アクション |
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KJ00006015164.pdf (3.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 腋窩リンパ節転移陽性乳癌における原発巣とリンパ節転移巣のHER2発現状況についての検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Assessment of HER2 Expression in Primary Lesions and their Metastatic Lymph Nodes in Breast Cancer Patients With Positive Axillary Lymph Nodes | |||||
著者名 |
竹尾, 幸子
× 竹尾, 幸子× 神尾, 孝子× 青山, 圭× 西川, 俊郎× 亀岡, 信悟 |
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著者別名 | ||||||
姓名 | TAKEO, Sachiko | |||||
著者別名 | ||||||
姓名 | KAMIO, Takako | |||||
著者別名 | ||||||
姓名 | AOYAMA, Kei | |||||
著者別名 | ||||||
姓名 | NISHIKAWA, Toshio | |||||
著者別名 | ||||||
姓名 | KAMEOKA, Shingo | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 78, 号 4, p. 189-197, 発行日 2008-04 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Human epidermal growth factor receptor type 2 (HER2) is a target protein of the gene-targeting drug trastuzumab. Since the prescription of trastuzumab is determined by the HER2 expression in primary tumors, it is essential to corroborate the HER2 expression in primary tumors and their metastatic lesions. Therefore, we compared the HER2 expression in the primary tumors of 107 postoperative cases with that in all 787 corresponding metastatic lymph nodes. In 74 of 107 cases (69.2%) HER2 scores between primary tumors and metastatic lymph nodes coincided however did not in 33 (30.8%). Maximal HER2 scores of metastatic lesions were lower than those in primary tumors in 13 of 33 cases. Conversely, metastatic lesions showed higher maximal scores than did primary tumors in 11 cases. Moreover, in 16 cases, HER2 scores were not uniform between different metastatic lesions in the same patient Primary tumors in 41 of 107 cases (38.3%) were found by heterogeneous staining. In 74 cases, in which HER2 scores were concordant between primary tumors and metastatic lesions, the primary tumors were not uniformly stained in 17 (23.0%). Of the remaining 33 cases, primary tumors were not uniformly stained in 24 (72.7%). Staining variability in metastatic lesions could have contributed to this heterogeneity of primary tumors. And this heterogeneity is one of the reasons for resistance to trastuzumab therapy. | |||||
著者所属 | ||||||
東京女子医科大学医学部第二外科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第二外科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第二外科学 | ||||||
著者所属 | ||||||
東京女子医科大学中央検査部 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第二外科学 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | HER2 | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | breast cancer | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | metastatic lymph nodes | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | trastuzumab |