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腎臓における酸化ストレス下のc-maf発現調節
http://hdl.handle.net/10470/27725
http://hdl.handle.net/10470/277252ca421e8-6b5d-4b13-9277-18b6c9a8c255
名前 / ファイル | ライセンス | アクション |
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KJ00006014805.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 腎臓における酸化ストレス下のc-maf発現調節 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Regulation of Oncogene c-maf Expression in the Kidney under Oxidative Stress | |||||
著者名 |
大石, 哲也
× 大石, 哲也× 芳田, 工× 杉浦, 秀和× 土谷, 健× 新田, 孝作 |
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著者別名 | ||||||
姓名 | OISHI, Tetsuya | |||||
著者別名 | ||||||
姓名 | YOSHIDA, Takumi | |||||
著者別名 | ||||||
姓名 | SUGIURA, Hidekazu | |||||
著者別名 | ||||||
姓名 | TSUCHIYA, Ken | |||||
著者別名 | ||||||
姓名 | NITTA, Kosaku | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 78, 号 1, p. 10-17, 発行日 2008-01 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Maf is a family of oncogenes that encode a transcription factors containing a typical bZip structure -a motif for protein dimerization and DNA binding- and have been speculated to possess various potentials in mediating development, cellular differentiation and biological activities in several organs. Previously, we reported that c-maf modulates the antioxidative pathway via plasma glutathione peroxidase-3 in the proximal tubules of the mouse kidney. Therefore, we suggested that c-maf might play an important role in the presence of oxidative stress in the kidney. Here, we investigated c-maf expression in a rat model for renal ischemia reperfusion injury and cultured cells derived from human kidney proximal tubular cells (HK-2) treated with several oxidative compounds. The in vivo and in vitro experiments demonstrated that the expression of c-maf mRNA was relatively low during the early stage of oxidative stress but increased at a later stage. An immunohistochemical study showed a reduction in c-maf protein over a similar time course. Tunel staining in HK-2 cells that were overexpressing c-maf showed a tendency toward a protective effect against H_2O_2, and the expression of the c-maf gene was related to a decrease in p21 and p53. These data indicate that c-maf depletion may trigger apoptotic cell death under stressful conditions, suggesting that the c-maf gene may be related to anti-stress related genes. | |||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | c-maf | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxidative stress | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | ischemic-reperfusion renal injury |