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The patients\u0027 ages at the start of treatment ranged from 2 years and 3 months to 18 years. Me-B_\u003c12\u003e was administered at a dosage of 25-30 g/kg/day for 6-25 months. The intelligence and developmental quotient (IQ/DQ) after Me-B_\u003c12\u003etreatment was 52±6.0 (mean ± SE), which was significantly higher than before treatment (45±5.3) (p\u003c0.05). The childhood autism rating scale (CARS) score improved significantly, from 35.9±1.6 before to 33.0±1.7 after treatment (p\u003c0.001). To distinguish the effects of Me-B_\u003c12\u003e from natural developmental factors, the patients were divided into two subgroups, both according to age and according to intelligence. The CARS scores of the teenage and the low-IQ groups improved as much as those of the pre-early school age and the high-IQ groups. 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A Preliminary Study of Methylcobalamin Therapy in Autism
http://hdl.handle.net/10470/26793
http://hdl.handle.net/10470/267939e460564-97da-450e-a0f0-7cde11f4ad39
名前 / ファイル | ライセンス | アクション |
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KJ00006018424.pdf (561.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | A Preliminary Study of Methylcobalamin Therapy in Autism | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | 自閉症におけるメチルコバラミン療法の予備的検討 | |||||
著者名 |
NAKANO, Kazutoshi
× NAKANO, Kazutoshi× NODA, Naoko× TACHIKAWA, Emiko× URANO, Mari× TAKAZAWA, Miyuki× NAKAYAMA, Tomohiro× SASAKI, Kaori× OSAWA, Makiko |
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著者別名 | ||||||
姓名 | 中野, 和俊 | |||||
著者別名 | ||||||
姓名 | 野田, 尚子 | |||||
著者別名 | ||||||
姓名 | 立川, 恵美子 | |||||
著者別名 | ||||||
姓名 | 浦野, 真理 | |||||
著者別名 | ||||||
姓名 | 高澤, みゆき | |||||
著者別名 | ||||||
姓名 | 中山, 智博 | |||||
著者別名 | ||||||
姓名 | 佐々木, 香織 | |||||
著者別名 | ||||||
姓名 | 大澤, 真木子 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 75, 号 3/4, p. 64-69, 発行日 2005-04 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 我々は13例の自閉症患者でビタミンB_<12>(メチルコバラミン:Me-B_<12>)の治療効果をオープン試験で試みた.Me-B_<12>の治療開始時期は2歳3ヵ月から18歳で,Me-B_<12>を25~30μg/kg/day,6~25ヵ月間投与した.IQ/DQによる評価では,治療前は45±5.3(平均±標準誤差)であったが,治療後は52±6.0と有意な上昇が認められた(p=0.0199).CARS検査(小児自閉症評定尺度)では,治療前は35.9±1.6であったが,治療後は33.0±1.7(p=0.0008)と改善した.自然経過による改善とMe-B_<12>効果を鑑別するため,患者を年齢,知能でそれぞれ2群に分類し検討したところ,思春期群と低IQ群のCARSスコアーが,幼児・早期学童期群,高IQ群と同様に改善した.自閉症児において思春期は一般に症状改善に乏しく,症状の自然改善は高機能自閉症児に見られることから,この結果は, Me-B_<12>効果は自然経過とは異なると考えられた.検討はまだ予備的段階であるが,自閉症においてMe-B_<12>は治療薬として試みる価値があると考えられた. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We conducted an open trial on the effect of methylcobalamin (Me-B_<12>) in 13 patients with autism. The patients' ages at the start of treatment ranged from 2 years and 3 months to 18 years. Me-B_<12> was administered at a dosage of 25-30 g/kg/day for 6-25 months. The intelligence and developmental quotient (IQ/DQ) after Me-B_<12>treatment was 52±6.0 (mean ± SE), which was significantly higher than before treatment (45±5.3) (p<0.05). The childhood autism rating scale (CARS) score improved significantly, from 35.9±1.6 before to 33.0±1.7 after treatment (p<0.001). To distinguish the effects of Me-B_<12> from natural developmental factors, the patients were divided into two subgroups, both according to age and according to intelligence. The CARS scores of the teenage and the low-IQ groups improved as much as those of the pre-early school age and the high-IQ groups. As adolescent autism patients usually show a decline in their condition, while some high function autism patients exhibit positive development, the improvement of CARS scores with Me-B_<12> treatment in the teenage and the low-IQ groups suggests that the Me-B_<12> effect is distinct from developmental factors. Although these data are very preliminary, Me-B_<12> is potentially beneficial in autism as an additional or alternative treatment. | |||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Tokyo Women's Medical University School of Medicine | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部小児科学 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | autism | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | IQ | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | methylcobalamin | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | childhood autism rating scale (CARS) | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | methylation cycle |