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Osteoprotegerin (OPG)は骨芽細胞の分化や骨吸収を修飾する因子として注目されているため,糖尿病を合併する透析患者の腎性骨症の病態に関与している可能性がある.本研究の目的は,インスリン非依存性の糖尿病を合併する血液透析愚者において,骨代謝マーカーとしての血清OPG濃度測定の意義に関して検討することである.対象は62例の維持透析患者(糖尿病合併は32例)で,平均年齢は57.1±1.3歳である.血清OPG濃度は市販のELISAキットで測定し,第2中手骨の骨密度はCXD(computed X-ray densitometry)法で計測した.骨代謝マーカーとして,副甲状腺ホルモン(iPTH),オステオカルシン(iOC)および骨型アルカリフォスファターゼ(BAP)も同時に測定した.透析患者の血清OPG濃度(240.9±13.1pg/ml)は,健常者(66.6±6.2pg/ml)に比して有意に増加していた. iPTH濃度により3群に分けた場合,各群間における血清OPG濃度には有意な差異を認めなかった.全症例における検討では,血清OPG濃度は骨代謝マーカーおよび骨密度との間に有意な相関はなかった.しかし,糖尿病合併例では,血清OPG濃度はiPTH濃度との間に正の相関(r=0.587, p\u003c0.01)を,骨密度との間には負の相関(r=-0.333, p\u003c0.05)を認めた.これらの結果から,糖尿病を合併する透析患者においては,低回転骨を併発している場合,血清OPG濃度が増加することで骨密度の低下を抑制している可能性があり,血清iPTH濃度とともに血清OPG濃度の測定は,腎性骨症の病態を把握するのに有用であると考えられた.", "subitem_description_type": "Abstract"}, {"subitem_description": "In diabetic patients with poor glycemic control, a reduction in bone mineral density (BMD) has been reported. Since osteoprotegerin (OPG) has an inhibitory effect on osteoclast differentiation and bone resorption, OPG might be involved in the pathogenesis of renal osteodystrophy (ROD) in diabetic patients receiving hemodialysis (HD). The aim of the present study was to examine the role of OPG in the bone metabolism of HD patients with noninsulin-dependent diabetes mellitus (NIDDM). Serum OPG levels were measured in 62 patients (32 diabetic and 30 non-diabetic) with a mean age of 57.1 ± 1.3 years using a sandwich enzyme immunoassay. Computed X-ray densitometry was used to measure BMD. Bone biochemical markers, such as intact parathyroid hormone (iPTH), osteocalcin and bone alkaline phosphatase, were determined simultaneously. Serum OPG levels were significantly increased in HD patients, compared with age-matched healthy volunteers (240.9 ± 13.1 vs 66.6 ± 6.2 pg/ml). No significant difference in serum OPG levels was observed in subgroups classified according to their serum iPTH levels. In addition, no significant correlation was observed between serum OPG levels and serum levels of bone metabolic markers or BMD in all HD patients. However, serum OPG levels were positively correlated with serum iPTH levels (r=0.587, p\u003c0.01) in HD patients with NIDDM. Moreover, a negative correlation was observed between serum OPG levels and BMD (r=-0.333, p\u003c0.05) in these patients. OPG may act as a counter-regulatory factor to prevent further bone loss in HD patients with NIDDM. 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Serum Osteoprotegerin Concentration and Bone Mineral Density in Hemodialysis Patients with Diabetes Mellitus
http://hdl.handle.net/10470/26717
http://hdl.handle.net/10470/26717ab0d39f7-8e2e-42a8-a639-a1e78436f0ac
名前 / ファイル | ライセンス | アクション |
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KJ00006019064.pdf (767.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | Serum Osteoprotegerin Concentration and Bone Mineral Density in Hemodialysis Patients with Diabetes Mellitus | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | 糖尿病を合併した血液透析患者における血清osteoprotegerjn濃度と骨密度の関連性 | |||||
著者名 |
SUZUKI, Keiko
× SUZUKI, Keiko× NITTA, Kosaku× UCHIDA, Keiko× AKIBA, Takashi× NIHEI, Hiroshi |
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著者別名 | ||||||
姓名 | 鈴木, 啓子 | |||||
著者別名 | ||||||
姓名 | 新田, 孝作 | |||||
著者別名 | ||||||
姓名 | 内田, 啓子 | |||||
著者別名 | ||||||
姓名 | 秋葉, 隆 | |||||
著者別名 | ||||||
姓名 | 二瓶, 宏 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 74, 号 11, p. 625-631, 発行日 2004-11-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 血糖コントロールが不良の糖尿病患者においては,骨密度の低下が認められることが報告されている. Osteoprotegerin (OPG)は骨芽細胞の分化や骨吸収を修飾する因子として注目されているため,糖尿病を合併する透析患者の腎性骨症の病態に関与している可能性がある.本研究の目的は,インスリン非依存性の糖尿病を合併する血液透析愚者において,骨代謝マーカーとしての血清OPG濃度測定の意義に関して検討することである.対象は62例の維持透析患者(糖尿病合併は32例)で,平均年齢は57.1±1.3歳である.血清OPG濃度は市販のELISAキットで測定し,第2中手骨の骨密度はCXD(computed X-ray densitometry)法で計測した.骨代謝マーカーとして,副甲状腺ホルモン(iPTH),オステオカルシン(iOC)および骨型アルカリフォスファターゼ(BAP)も同時に測定した.透析患者の血清OPG濃度(240.9±13.1pg/ml)は,健常者(66.6±6.2pg/ml)に比して有意に増加していた. iPTH濃度により3群に分けた場合,各群間における血清OPG濃度には有意な差異を認めなかった.全症例における検討では,血清OPG濃度は骨代謝マーカーおよび骨密度との間に有意な相関はなかった.しかし,糖尿病合併例では,血清OPG濃度はiPTH濃度との間に正の相関(r=0.587, p<0.01)を,骨密度との間には負の相関(r=-0.333, p<0.05)を認めた.これらの結果から,糖尿病を合併する透析患者においては,低回転骨を併発している場合,血清OPG濃度が増加することで骨密度の低下を抑制している可能性があり,血清iPTH濃度とともに血清OPG濃度の測定は,腎性骨症の病態を把握するのに有用であると考えられた. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In diabetic patients with poor glycemic control, a reduction in bone mineral density (BMD) has been reported. Since osteoprotegerin (OPG) has an inhibitory effect on osteoclast differentiation and bone resorption, OPG might be involved in the pathogenesis of renal osteodystrophy (ROD) in diabetic patients receiving hemodialysis (HD). The aim of the present study was to examine the role of OPG in the bone metabolism of HD patients with noninsulin-dependent diabetes mellitus (NIDDM). Serum OPG levels were measured in 62 patients (32 diabetic and 30 non-diabetic) with a mean age of 57.1 ± 1.3 years using a sandwich enzyme immunoassay. Computed X-ray densitometry was used to measure BMD. Bone biochemical markers, such as intact parathyroid hormone (iPTH), osteocalcin and bone alkaline phosphatase, were determined simultaneously. Serum OPG levels were significantly increased in HD patients, compared with age-matched healthy volunteers (240.9 ± 13.1 vs 66.6 ± 6.2 pg/ml). No significant difference in serum OPG levels was observed in subgroups classified according to their serum iPTH levels. In addition, no significant correlation was observed between serum OPG levels and serum levels of bone metabolic markers or BMD in all HD patients. However, serum OPG levels were positively correlated with serum iPTH levels (r=0.587, p<0.01) in HD patients with NIDDM. Moreover, a negative correlation was observed between serum OPG levels and BMD (r=-0.333, p<0.05) in these patients. OPG may act as a counter-regulatory factor to prevent further bone loss in HD patients with NIDDM. The determination of serum OPG levels in combination with iPTH can be used as a marker for the noninvasive diagnosis of ROD in these patients. | |||||
著者所属 | ||||||
Department of Medicine IV, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Medicine IV, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Medicine IV, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Medicine IV, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
Department of Medicine IV, Tokyo Women's Medical University, School of Medicine | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoprotegerin | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | hemodialysis | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone mineral density | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | diabetes mellitus | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | parathyroid hormone |