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ラット腎虚血再灌流モデルにおけるklothoの発現調節
http://hdl.handle.net/10470/26568
http://hdl.handle.net/10470/2656830ffa3e1-2b5b-40f2-a385-afee2ebe6346
名前 / ファイル | ライセンス | アクション |
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KJ00006018886.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | ラット腎虚血再灌流モデルにおけるklothoの発現調節 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Regulation of Klotho Expression in the Experimental Ischemic-Reperfusion Renal Injury Model | |||||
著者名 |
杉浦, 秀和
× 杉浦, 秀和× 芳田, 工× 土谷, 健× 三戸部, 倫大× 二瓶, 宏 |
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著者別名 | ||||||
姓名 | SUGIURA, Hidekazu | |||||
著者別名 | ||||||
姓名 | YOSHIDA, Takumi | |||||
著者別名 | ||||||
姓名 | TSUCHIYA, Ken | |||||
著者別名 | ||||||
姓名 | MITOBE, Michihiro | |||||
著者別名 | ||||||
姓名 | NIHEI, Hiroshi | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 74, 号 6/7, p. 314-320, 発行日 2004-07 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A new gene, klotho, is associated with the suppression of several aging phenotypes. High expression of the klotho gene was detected in the kidney and several studies have reported the alternation of its expression level in some animal models and stressful conditions, so we explored the physiological relevance of the klotho expression in the kidney following ischemic-reperfusion renal injury (IRI). Male Wistar rats underwent bilateral renal ischemia or sham operation, followed by reperfusion for 1, 3 and 10 days. The expression of renal klotho mRNA and protein was assessed with real-time PCR or Western blotting. Creatinine levels were determined for functional parameters. Immunohistochemical and morphological studies were performed. Apoptotic cells were determined by TUNEL staining. Renal klotho mRNA and protein expression was significantly reduced in IRI rats the first day after ischemia. The number of klotho positive cells in the kidney 3 days after IRI was less than that in the sham-operated kidney. In addition, both TUNEL and klotho staining showed co-localization. The data indicated that the klotho gene is implicated in the pathophysiology associated with IRI. Downregulation of the renal klotho gene plays a role in the aggravation of ischemic acute renal failure. | |||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第四内科学 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | ischemic-reperfusion renal injury | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | klotho |