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It has been considered that consequence of clinical course of HBV infection is depend on factors in an infected host because continuous infection takes place on vertical infection, from mother to child, on the other hand transient infection is observed only in an adult case. Recently, it has been reported that genotype difference of HBV affects clinical course of infection of adult case, so factors of not only host but also HBV could influence the outcome of infection. I think \"transient infection\" and \"continuous infection\" is an adequate terminology. 2. The clinical course of HBV infection could be determined into four phases consisted of incubation, clinical, recovering and healing state, whatever an infectious condition is transient or continuous. The duration of these four phases in transient infection is consistent, however, that of continuous infection is unexpected in an each patient case and furthermore duration of one phase extends years or more than ten years. 3. In an incubation period of continuous infection, two types of condition are recognizable; one is a pure carrier state without inflammation and another is a \"subclinical hepatitis\" with slight inflammation which is characterized with high anti-HBc Ab and transient slight elevation of transaminase less than two fold of normal limit. 4. It is important to recognize the risk of hepatocarcinogenesis even in a case showing almost normal liver function test, anti-HBeAb positive and pathologically very faint inflammation in liver biopsy specimen. 5.I have experienced six cases of continuous HBV infection in which HBsAg turned out to be negative in a long follow up. The loss of HBsAg took place 4-5 years after liver function test recovered to a normal range, and repeating liver biopsy examinations revealed an excellent improvement of inflammation. A half of cases showed positive for HBV DNA in serum. 6. 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HBVウイルス感染症の自然経過について
http://hdl.handle.net/10470/26375
http://hdl.handle.net/10470/26375ae431f55-bc01-49a4-ad8e-77564c248df5
名前 / ファイル | ライセンス | アクション |
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KJ00006019427.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | HBVウイルス感染症の自然経過について | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Natural Course of HBV Infection | |||||
著者名 |
林, 直諒
× 林, 直諒 |
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著者別名 | ||||||
姓名 | HAYASHI, Naoaki | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 73, 号 12, p. 531-539, 発行日 2003-12-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The important points I discussed here are these six points as follows : 1. It has been considered that consequence of clinical course of HBV infection is depend on factors in an infected host because continuous infection takes place on vertical infection, from mother to child, on the other hand transient infection is observed only in an adult case. Recently, it has been reported that genotype difference of HBV affects clinical course of infection of adult case, so factors of not only host but also HBV could influence the outcome of infection. I think "transient infection" and "continuous infection" is an adequate terminology. 2. The clinical course of HBV infection could be determined into four phases consisted of incubation, clinical, recovering and healing state, whatever an infectious condition is transient or continuous. The duration of these four phases in transient infection is consistent, however, that of continuous infection is unexpected in an each patient case and furthermore duration of one phase extends years or more than ten years. 3. In an incubation period of continuous infection, two types of condition are recognizable; one is a pure carrier state without inflammation and another is a "subclinical hepatitis" with slight inflammation which is characterized with high anti-HBc Ab and transient slight elevation of transaminase less than two fold of normal limit. 4. It is important to recognize the risk of hepatocarcinogenesis even in a case showing almost normal liver function test, anti-HBeAb positive and pathologically very faint inflammation in liver biopsy specimen. 5.I have experienced six cases of continuous HBV infection in which HBsAg turned out to be negative in a long follow up. The loss of HBsAg took place 4-5 years after liver function test recovered to a normal range, and repeating liver biopsy examinations revealed an excellent improvement of inflammation. A half of cases showed positive for HBV DNA in serum. 6. To determine effectiveness of treatment it may require a long observation around five years and it is impossible to obtain worldwide definition of effectiveness of treatment if we could not establish a clinical standard. | |||||
著者所属 | ||||||
東京女子医科大学消化器病センター消化器内科 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | natural course | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | healthy carrier | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | seroconversion | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | HBV | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | subclinical hepatitis |